Molecular magnetic resonance contrast agents for the detection of cancer: past and present
UMass Chan Affiliations
Department of RadiologyDocument Type
Journal ArticlePublication Date
2011-02-01Keywords
Contrast MediaHumans
Magnetic Resonance Imaging
Molecular Imaging
Molecular Probes
Neoplasms
Diagnosis
Equipment and Supplies
Investigative Techniques
Neoplasms
Radiology
Metadata
Show full item recordAbstract
Magnetic resonance imaging (MRI) is a powerful diagnostic tool with unsurpassed spatial resolution that is capable of providing detailed information about the structure and composition of tumors. The use of exogenously administered contrast agents allows compartment-specific enhancement of tumors, enabling imaging of functional blood and interstitial volumes. Current efforts are directed at enhancing the capabilities of MRI in oncology by adding contrast agents with molecular specificities to the growing armamentarium of diagnostic probes that produce signal by changing local proton relaxation times as a consequence of specific contrast agent binding to cell surface receptors or extracellular matrix components. We review herein the most notable examples, illustrating major trends in the development of specific probes for high-resolution imaging in molecular oncology.Source
Semin Oncol. 2011 Feb;38(1):42-54. doi: 10.1053/j.seminoncol.2010.11.002. Link to article on publisher's siteDOI
10.1053/j.seminoncol.2010.11.002Permanent Link to this Item
http://hdl.handle.net/20.500.14038/48612PubMed ID
21362515Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1053/j.seminoncol.2010.11.002