Consensus nomenclature for dyneins and associated assembly factors
Authors
Braschi, BryonyOmran, Heymut
Witman, George B.
Pazour, Gregory J.
Pfister, K. Kevin
Bruford, Elspeth A.
King, Stephen M.
UMass Chan Affiliations
Witman LabProgram in Molecular Medicine
Division of Cell Biology and Imaging, Department of Radiology
Document Type
Journal ArticlePublication Date
2022-01-10
Metadata
Show full item recordAbstract
Dyneins are highly complex, multicomponent, microtubule-based molecular motors. These enzymes are responsible for numerous motile behaviors in cytoplasm, mediate retrograde intraflagellar transport (IFT), and power ciliary and flagellar motility. Variants in multiple genes encoding dyneins, outer dynein arm (ODA) docking complex subunits, and cytoplasmic factors involved in axonemal dynein preassembly (DNAAFs) are associated with human ciliopathies and are of clinical interest. Therefore, clear communication within this field is particularly important. Standardizing gene nomenclature, and basing it on orthology where possible, facilitates discussion and genetic comparison across species. Here, we discuss how the human gene nomenclature for dyneins, ODA docking complex subunits, and DNAAFs has been updated to be more functionally informative and consistent with that of the unicellular green alga Chlamydomonas reinhardtii, a key model organism for studying dyneins and ciliary function. We also detail additional nomenclature updates for vertebrate-specific genes that encode dynein chains and other proteins involved in dynein complex assembly.Source
Braschi B, Omran H, Witman GB, Pazour GJ, Pfister KK, Bruford EA, King SM. Consensus nomenclature for dyneins and associated assembly factors. J Cell Biol. 2022 Feb 7;221(2):e202109014. doi: 10.1083/jcb.202109014. Epub 2022 Jan 10. PMID: 35006274; PMCID: PMC8754002. Link to article on publisher's site
DOI
10.1083/jcb.202109014Permanent Link to this Item
http://hdl.handle.net/20.500.14038/48622PubMed ID
35006274Related Resources
Rights
© 2021 Braschi et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).Distribution License
http://creativecommons.org/licenses/by/4.0/ae974a485f413a2113503eed53cd6c53
10.1083/jcb.202109014
Scopus Count
Except where otherwise noted, this item's license is described as © 2021 Braschi et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).