The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis
AuthorsRanger, Ann M.
Gerstenfeld, Louis C.
Gravallese, Ellen M.
Glimcher, Melvin J.
Glimcher, Laurie H.
UMass Chan AffiliationsDepartment of Medicine, Division of Rheumatology
Document TypeJournal Article
Bone and Bones
Genes, Tumor Suppressor
Mice, Inbred BALB C
NFATC Transcription Factors
mesenchymal stem cells
Cellular and Molecular Physiology
MetadataShow full item record
AbstractNuclear factor of activated T cells (NFAT) transcription factors regulate gene expression in lymphocytes and control cardiac valve formation. Here, we report that NFATp regulates chondrogenesis in the adult animal. In mice lacking NFATp, resident cells in the extraarticular connective tissues spontaneously differentiate to cartilage. These cartilage cells progressively differentiate and the tissue undergoes endochondral ossification, recapitulating the development of endochondral bone. Proliferation of already existing articular cartilage cells also occurs in some older animals. At both sites, neoplastic changes in the cartilage cells occur. Consistent with these data, NFATp expression is regulated in mesenchymal stem cells induced to differentiate along a chondrogenic pathway. Lack of NFATp in articular cartilage cells results in increased expression of cartilage markers, whereas overexpression of NFATp in cartilage cell lines extinguishes the cartilage phenotype. Thus, NFATp is a repressor of cartilage cell growth and differentiation and also has the properties of a tumor suppressor.
SourceJ Exp Med. 2000 Jan 3;191(1):9-22. doi: 10.1084/jem.191.1.9. Link to article on publisher's website
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/48739
At the time of publication, Ellen Gravallese was not yet affiliated with the University of Massachusetts Medical School.
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