The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis
Authors
Ranger, Ann M.Gerstenfeld, Louis C.
Wang, Jinxi
Kon, Tamiyo
Bae, Hyunsu
Gravallese, Ellen M.
Glimcher, Melvin J.
Glimcher, Laurie H.
UMass Chan Affiliations
Department of Medicine, Division of RheumatologyDocument Type
Journal ArticlePublication Date
2000-01-03Keywords
AnimalsBone Development
Bone and Bones
Cartilage
Cell Differentiation
Cell Division
*Chondrogenesis
DNA-Binding Proteins
Genes, Tumor Suppressor
Mice
Mice, Inbred BALB C
Mice, Knockout
NFATC Transcription Factors
*Nuclear Proteins
Stem Cells
Transcription Factors
cartilage
NFATp
mesenchymal stem cells
chondrosarcoma
differentiation
Cancer Biology
Cell Biology
Cellular and Molecular Physiology
Metadata
Show full item recordAbstract
Nuclear factor of activated T cells (NFAT) transcription factors regulate gene expression in lymphocytes and control cardiac valve formation. Here, we report that NFATp regulates chondrogenesis in the adult animal. In mice lacking NFATp, resident cells in the extraarticular connective tissues spontaneously differentiate to cartilage. These cartilage cells progressively differentiate and the tissue undergoes endochondral ossification, recapitulating the development of endochondral bone. Proliferation of already existing articular cartilage cells also occurs in some older animals. At both sites, neoplastic changes in the cartilage cells occur. Consistent with these data, NFATp expression is regulated in mesenchymal stem cells induced to differentiate along a chondrogenic pathway. Lack of NFATp in articular cartilage cells results in increased expression of cartilage markers, whereas overexpression of NFATp in cartilage cell lines extinguishes the cartilage phenotype. Thus, NFATp is a repressor of cartilage cell growth and differentiation and also has the properties of a tumor suppressor.Source
J Exp Med. 2000 Jan 3;191(1):9-22. doi: 10.1084/jem.191.1.9. Link to article on publisher's websiteDOI
10.1084/jem.191.1.9Permanent Link to this Item
http://hdl.handle.net/20.500.14038/48739PubMed ID
10620601Notes
At the time of publication, Ellen Gravallese was not yet affiliated with the University of Massachusetts Medical School.
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http://creativecommons.org/licenses/by-nc/3.0/ae974a485f413a2113503eed53cd6c53
10.1084/jem.191.1.9
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Except where otherwise noted, this item's license is described as <p>Publisher PDF posted as allowed by the publisher's author rights policy at http://www.rupress.org/site/subscriptions/terms.xhtml.</p>
<p>Beginning six months after publication, RUP grants the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license</p>