The role of TNF-receptor family members and other TRAF-dependent receptors in bone resorption
UMass Chan Affiliations
Department of Medicine, Division of RheumatologyDocument Type
Journal ArticlePublication Date
2001-02-15Keywords
AnimalsBone Resorption
Carrier Proteins
Cell Differentiation
Glycoproteins
Humans
Membrane Glycoproteins
Osteoprotegerin
Proteins
RANK LigandReceptor Activator of Nuclear Factor-kappa BReceptors, Cytoplasmic and NuclearReceptors, Tumor Necrosis FactorSignal TransductionTNF Receptor-Associated Factor 1TNF Receptor-Associated Factor 2TNF Receptor-Associated Factor 3TNF Receptor-Associated Factor 4TNF Receptor-Associated Factor 5TNF Receptor-Associated Factor 6Tumor Necrosis Factor Receptor-Associated Peptides and ProteinsosteoclastsRANKRANKLTNF-αTRAFCellular and Molecular PhysiologyMusculoskeletal DiseasesRheumatologySkin and Connective Tissue Diseases
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Show full item recordAbstract
The contribution of osteoclasts to the process of bone loss in inflammatory arthritis has recently been demonstrated. Studies in osteoclast biology have led to the identification of factors responsible for the differentiation and activation of osteoclasts, the most important of which is the receptor activator of NF-kappa B ligand/osteoclast differentiation factor (RANKL/ODF), a tumor necrosis factor (TNF)-like protein. The RANKL/ODF receptor, receptor activator of NF-kappa B (RANK), is a TNF-receptor family member present on both osteoclast precursors and mature osteoclasts. Like other TNF-family receptors and the IL-1 receptor, RANK mediates its signal transduction via TNF receptor-associated factor (TRAF) proteins, suggesting that the signaling pathways activated by RANK and other inflammatory cytokines involved in osteoclast differentiation and activation are interconnected.Source
Arthritis Res. 2001;3(1):6-12. Epub 2000 Nov 2. doi:10.1186/ar134. Link to article on publisher's siteDOI
10.1186/ar134Permanent Link to this Item
http://hdl.handle.net/20.500.14038/48742PubMed ID
11178122Notes
At the time of publication, Ellen Gravallese was not yet affiliated with the University of Massachusetts Medical School.
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Publisher PDF posted as allowed by the publisher's copyright policy at http://arthritis-research.com/about.
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