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    Hand bone mineral density is associated with both total hip and lumbar spine bone mineral density in post-menopausal women with RA

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    Authors
    Desai, Sonali P.
    Gravallese, Ellen M.
    Shadick, Nancy A.
    Glass, Roberta
    Cui, Jing
    Frits, Michelle
    Chibnik, Lori B.
    Maher, Nancy
    Weinblatt, Michael E.
    Solomon, Daniel H.
    UMass Chan Affiliations
    Department of Medicine, Division of Rheumatology
    Document Type
    Journal Article
    Publication Date
    2010-03-01
    Keywords
    Absorptiometry, Photon
    Age Factors
    Aged
    Arthritis, Rheumatoid
    Bone Density
    Cross-Sectional Studies
    Epidemiologic Methods
    Female
    Hip Joint
    Humans
    Lumbar Vertebrae
    Metacarpal Bones
    Middle Aged
    Postmenopause
    Time Factors
    Musculoskeletal Diseases
    Rheumatology
    Skin and Connective Tissue Diseases
    Women's Health
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    Link to Full Text
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820263/
    Abstract
    OBJECTIVE: RA is associated with localized bone loss in the hands, as well as generalized osteoporosis. We evaluated the relationship between hand digital X-ray radiogrammetry BMD (DXR-BMD) and total hip and lumbar spine BMD. METHODS: We conducted a cross-sectional study of 138 post-menopausal women with RA. The DXR-BMD was calculated based on digitized hand radiographs. Measurements of the total hip and lumbar spine BMD were performed by a DXA-BMD (BMDa) scan. Patient and physician questionnaires and laboratory samples supplied information on relevant covariates. Separate multivariate linear regression models were constructed to determine the cross-sectional relationship between hand DXR-BMD (independent variable) and total hip or lumbar spine BMD (dependent variables). RESULTS: The cohort comprised women with a median age of 61 years and RA disease duration of 13 years. Seventy-six per cent were either RF and/or anti-cyclic citrullinated peptide (anti-CCP) positive and most had moderate disease activity [median disease activity score-28 joint count (DAS28) 3.7]. Hand DXR-BMD was significantly associated with total hip BMD (beta = 0.61; P < 0.0001) and lumbar spine BMD (beta = 0.62; P < 0.0008) in adjusted models. CONCLUSIONS: This study suggests that hand DXR-BMD is associated with both the total hip and lumbar spine BMD among post-menopausal women with RA. The relationship between bone loss in the hands and generalized osteoporosis should be further explored in longitudinal studies of patients with RA.
    Source
    Rheumatology (Oxford). 2010 Mar;49(3):513-9. doi: 10.1093/rheumatology/kep385. Epub 2009 Dec 21. Link to article on publisher's site
    DOI
    10.1093/rheumatology/kep385
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/48748
    PubMed ID
    20026562
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1093/rheumatology/kep385
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