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    Mechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implications

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    Authors
    Goldring, Steven R.
    Gravallese, Ellen M.
    UMass Chan Affiliations
    Department of Medicine, Division of Rheumatology
    Document Type
    Journal Article
    Publication Date
    2000-12-22
    Keywords
    Arthritis, Rheumatoid
    Bone Density
    Female
    Humans
    Joints
    Male
    *Osteoporosis
    bone loss
    cytokines
    osteoclast
    osteoporosis
    rheumatoid arthritis
    Musculoskeletal Diseases
    Rheumatology
    Skin and Connective Tissue Diseases
    Therapeutics
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    Abstract
    Rheumatoid arthritis represents an excellent model in which to gain insights into the local and systemic effects of joint inflammation on skeletal tissues. Three forms of bone disease have been described in rheumatoid arthritis. These include: focal bone loss affecting the immediate subchondral bone and bone at the joint margins; periarticular osteopenia adjacent to inflamed joints; and generalized osteoporosis involving the axial and appendicular skeleton. Although these three forms of bone loss have several features in common, careful histomorphometric and histopathological analysis of bone tissues from different skeletal sites, as well as the use of urinary and serum biochemical markers of bone remodeling, provide compelling evidence that different mechanisms are involved in their pathogenesis. An understanding of these distinct pathological forms of bone loss has relevance not only with respect to gaining insights into the different pathological mechanisms, but also for developing specific and effective strategies for preventing the different forms of bone loss in rheumatoid arthritis.
    Source
    Arthritis Res. 2000;2(1):33-7. Epub 1999 Dec 22. Link to article on publisher's site
    DOI
    10.1186/ar67
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/48753
    PubMed ID
    11094416
    Notes

    At the time of publication, Ellen Gravallese was not yet affiliated with the University of Massachusetts Medical School.

    Related Resources
    Link to Article in PubMed
    Rights

    This publication is open access and the publisher PDF posted as allowed by the publisher's copyright policy at http://arthritis-research.com/about.

    ae974a485f413a2113503eed53cd6c53
    10.1186/ar67
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