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Mechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implications
UMass Chan Affiliations
Department of Medicine, Division of RheumatologyDocument Type
Journal ArticlePublication Date
2000-12-22Keywords
Arthritis, RheumatoidBone Density
Female
Humans
Joints
Male
*Osteoporosis
bone loss
cytokines
osteoclast
osteoporosis
rheumatoid arthritis
Musculoskeletal Diseases
Rheumatology
Skin and Connective Tissue Diseases
Therapeutics
Metadata
Show full item recordAbstract
Rheumatoid arthritis represents an excellent model in which to gain insights into the local and systemic effects of joint inflammation on skeletal tissues. Three forms of bone disease have been described in rheumatoid arthritis. These include: focal bone loss affecting the immediate subchondral bone and bone at the joint margins; periarticular osteopenia adjacent to inflamed joints; and generalized osteoporosis involving the axial and appendicular skeleton. Although these three forms of bone loss have several features in common, careful histomorphometric and histopathological analysis of bone tissues from different skeletal sites, as well as the use of urinary and serum biochemical markers of bone remodeling, provide compelling evidence that different mechanisms are involved in their pathogenesis. An understanding of these distinct pathological forms of bone loss has relevance not only with respect to gaining insights into the different pathological mechanisms, but also for developing specific and effective strategies for preventing the different forms of bone loss in rheumatoid arthritis.Source
Arthritis Res. 2000;2(1):33-7. Epub 1999 Dec 22. Link to article on publisher's siteDOI
10.1186/ar67Permanent Link to this Item
http://hdl.handle.net/20.500.14038/48753PubMed ID
11094416Notes
At the time of publication, Ellen Gravallese was not yet affiliated with the University of Massachusetts Medical School.
Related Resources
Link to Article in PubMedRights
This publication is open access and the publisher PDF posted as allowed by the publisher's copyright policy at http://arthritis-research.com/about.
ae974a485f413a2113503eed53cd6c53
10.1186/ar67