Authors
Gravallese, Ellen M.UMass Chan Affiliations
Department of Medicine, Division of RheumatologyDocument Type
Response or CommentPublication Date
2003-07-17Keywords
AnimalsArthritis, Rheumatoid
Disease Models, Animal
Epitopes
Inflammation
Mice
Mice, Inbred C57BL
Osteopontin
RNA, Messenger
Sialoglycoproteins
osteopontin
rheumatoid arthritis
Cells
Medical Immunology
Musculoskeletal Diseases
Rheumatology
Skin and Connective Tissue Diseases
Metadata
Show full item recordAbstract
The molecular mechanisms underlying the putative role of osteopontin in the chronic inflammatory disease rheumatoid arthritis are unclear. A study in a murine model of arthritis now demonstrates that a specific antibody directed against the exposed osteopontin epitope SLAYGLR is capable of preventing inflammatory cell infiltration in arthritic joints.Source
J Clin Invest. 2003 Jul;112(2):147-9. Link to article on publisher's siteDOI
10.1172/JCI19190Permanent Link to this Item
http://hdl.handle.net/20.500.14038/48755PubMed ID
12865402Notes
At the time of publication, Ellen Gravallese was not yet affiliated with the University of Massachusetts Medical School.
Related Resources
Link to Article in PubMedRights
Publisher PDF posted as allowed by the publisher's author rights policy at http://static.the-jci.org/content_assets/admin/forms/jcicopyright.pdf.
ae974a485f413a2113503eed53cd6c53
10.1172/JCI19190