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dc.contributor.authorMatsuyama, Takami
dc.contributor.authorYamada, Akira
dc.contributor.authorKay, Jonathan
dc.contributor.authorYamada, Kenneth M.
dc.contributor.authorAkiyama, Steven K.
dc.contributor.authorSchlossman, Stuart F.
dc.contributor.authorMorimoto, Chikao
dc.date2022-08-11T08:10:51.000
dc.date.accessioned2022-08-23T17:22:30Z
dc.date.available2022-08-23T17:22:30Z
dc.date.issued1989-10-01
dc.date.submitted2015-04-17
dc.identifier.citationJ Exp Med. 1989 Oct 1;170(4):1133-48.
dc.identifier.issn0022-1007 (Linking)
dc.identifier.pmid2477485
dc.identifier.urihttp://hdl.handle.net/20.500.14038/48762
dc.description<p>At the time of publication, Jonathan Kay was not yet affiliated with the University of Massachusetts Medical School.</p>
dc.description.abstractIn this study, fibronectin synergized with anti-CD3 antibody to promote CD4 cell proliferation in a serum-free culture system. The cell-adhesive domain plus additional regions of the fibronectin molecule are involved in this synergy. Anti4B4(CDw29) antibody blocked the activation of CD4 cells in this system. Furthermore, it is the VLA-5 protein within the set of molecules recognized by anti-4B4 that serves as a fibronectin receptor on the CD4 lymphocytes. The VLA-5 fibronectin receptor was mainly expressed on CD4+ CD45R-CDw29+ cells and may in part contribute to the unique function of these cells.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=2477485&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189458/
dc.subjectAntibodies, Monoclonal
dc.subjectAntigens, CD29
dc.subjectAntigens, CD3
dc.subjectAntigens, Differentiation
dc.subjectAntigens, Differentiation, T-Lymphocyte
dc.subjectCD4-Positive T-Lymphocytes
dc.subjectCells, Cultured
dc.subjectElectrophoresis, Gel, Two-Dimensional
dc.subjectExtracellular Matrix
dc.subjectFibronectins
dc.subjectHumans
dc.subjectIn Vitro Techniques
dc.subject*Lymphocyte Activation
dc.subjectReceptors, Antigen, T-Cell
dc.subjectReceptors, Cytoadhesin
dc.subjectReceptors, Very Late Antigen
dc.subjectImmunology and Infectious Disease
dc.subjectMusculoskeletal Diseases
dc.subjectRheumatology
dc.subjectSkin and Connective Tissue Diseases
dc.titleActivation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex
dc.typeJournal Article
dc.source.journaltitleThe Journal of experimental medicine
dc.source.volume170
dc.source.issue4
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1073&amp;context=rheumatology_pubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/rheumatology_pubs/74
dc.identifier.contextkey7002897
refterms.dateFOA2022-08-23T17:22:31Z
html.description.abstract<p>In this study, fibronectin synergized with anti-CD3 antibody to promote CD4 cell proliferation in a serum-free culture system. The cell-adhesive domain plus additional regions of the fibronectin molecule are involved in this synergy. Anti4B4(CDw29) antibody blocked the activation of CD4 cells in this system. Furthermore, it is the VLA-5 protein within the set of molecules recognized by anti-4B4 that serves as a fibronectin receptor on the CD4 lymphocytes. The VLA-5 fibronectin receptor was mainly expressed on CD4+ CD45R-CDw29+ cells and may in part contribute to the unique function of these cells.</p>
dc.identifier.submissionpathrheumatology_pubs/74
dc.contributor.departmentDepartment of Medicine, Division of Rheumatology
dc.source.pages1133-48


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