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dc.contributor.authorRivera-Pérez, Jaime A.
dc.contributor.authorMallo, Moises
dc.contributor.authorGendron-Maguire, Maureen
dc.contributor.authorGridley, Thomas
dc.contributor.authorBehringer, Richard R.
dc.date2022-08-11T08:10:51.000
dc.date.accessioned2022-08-23T17:22:35Z
dc.date.available2022-08-23T17:22:35Z
dc.date.issued1995-09-01
dc.date.submitted2011-02-03
dc.identifier.citationDevelopment. 1995 Sep;121(9):3005-12. <a href="http://dev.biologists.org/content/121/9/3005.full.pdf+html">Link to article on publisher's website</a>
dc.identifier.issn0950-1991 (Linking)
dc.identifier.pmid7555726
dc.identifier.urihttp://hdl.handle.net/20.500.14038/48777
dc.description.abstractGoosecoid (gsc) is an evolutionarily conserved homeobox gene expressed in the gastrula organizer region of a variety of vertebrate embryos, including zebrafish, Xenopus, chicken and mouse. To understand the role of gsc during mouse embryogenesis, we generated gsc-null mice by gene targeting in embryonic stem cells. Surprisingly, gsc-null embryos gastrulated and formed the primary body axes; gsc-null mice were born alive but died soon after birth with numerous craniofacial defects. In addition, rib fusions and sternum abnormalities were detected that varied depending upon the genetic background. Transplantation experiments suggest that the ovary does not provide gsc function to rescue gastrulation defects. These results demonstrate that gsc is not essential for organizer activity in the mouse but is required later during embryogenesis for craniofacial and rib cage development.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=7555726&dopt=Abstract">Link to Article in PubMed</a>
dc.subjectAnimals
dc.subjectDNA-Binding Proteins
dc.subjectFacial Bones
dc.subjectFemale
dc.subjectFetal Death
dc.subjectGastrula
dc.subjectGene Expression
dc.subjectGene Targeting
dc.subject*Genes, Homeobox
dc.subjectGoosecoid Protein
dc.subject*Homeodomain Proteins
dc.subjectMice
dc.subjectMice, Mutant Strains
dc.subjectMorphogenesis
dc.subjectPhenotype
dc.subject*Repressor Proteins
dc.subjectRibs
dc.subjectSkull
dc.subject*Transcription Factors
dc.subjectCell Biology
dc.titleGoosecoid is not an essential component of the mouse gastrula organizer but is required for craniofacial and rib development
dc.typeJournal Article
dc.source.journaltitleDevelopment (Cambridge, England)
dc.source.volume121
dc.source.issue9
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1012&amp;context=rivera&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/rivera/13
dc.identifier.contextkey1762247
refterms.dateFOA2022-08-23T17:22:35Z
html.description.abstract<p>Goosecoid (gsc) is an evolutionarily conserved homeobox gene expressed in the gastrula organizer region of a variety of vertebrate embryos, including zebrafish, Xenopus, chicken and mouse. To understand the role of gsc during mouse embryogenesis, we generated gsc-null mice by gene targeting in embryonic stem cells. Surprisingly, gsc-null embryos gastrulated and formed the primary body axes; gsc-null mice were born alive but died soon after birth with numerous craniofacial defects. In addition, rib fusions and sternum abnormalities were detected that varied depending upon the genetic background. Transplantation experiments suggest that the ovary does not provide gsc function to rescue gastrulation defects. These results demonstrate that gsc is not essential for organizer activity in the mouse but is required later during embryogenesis for craniofacial and rib cage development.</p>
dc.identifier.submissionpathrivera/13
dc.contributor.departmentDepartment of Cell Biology
dc.source.pages3005-12


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