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dc.contributor.authorLewis, Samuel H.
dc.contributor.authorYang, Yujing
dc.contributor.authorZamore, Phillip D.
dc.contributor.authorJiggins, Francis M.
dc.date2022-08-11T08:10:52.000
dc.date.accessioned2022-08-23T17:22:50Z
dc.date.available2022-08-23T17:22:50Z
dc.date.issued2018-01-01
dc.date.submitted2018-07-20
dc.identifier.citation<p>Nat Ecol Evol. 2018 Jan;2(1):174-181. doi: 10.1038/s41559-017-0403-4. Epub 2017 Dec 4. <a href="https://doi.org/10.1038/s41559-017-0403-4">Link to article on publisher's site</a></p>
dc.identifier.issn2397-334X (Linking)
dc.identifier.doi10.1038/s41559-017-0403-4
dc.identifier.pmid29203920
dc.identifier.urihttp://hdl.handle.net/20.500.14038/48828
dc.description.abstractIn animals, small RNA molecules termed PIWI-interacting RNAs (piRNAs) silence transposable elements (TEs), protecting the germline from genomic instability and mutation. piRNAs have been detected in the soma in a few animals, but these are believed to be specific adaptations of individual species. Here, we report that somatic piRNAs were probably present in the ancestral arthropod more than 500 million years ago. Analysis of 20 species across the arthropod phylum suggests that somatic piRNAs targeting TEs and messenger RNAs are common among arthropods. The presence of an RNA-dependent RNA polymerase in chelicerates (horseshoe crabs, spiders and scorpions) suggests that arthropods originally used a plant-like RNA interference mechanism to silence TEs. Our results call into question the view that the ancestral role of the piRNA pathway was to protect the germline and demonstrate that small RNA silencing pathways have been repurposed for both somatic and germline functions throughout arthropod evolution.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=29203920&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732027/
dc.subjectBiochemistry, Biophysics, and Structural Biology
dc.subjectCell and Developmental Biology
dc.subjectEcology and Evolutionary Biology
dc.subjectGenetics and Genomics
dc.subjectTherapeutics
dc.titlePan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements
dc.typeJournal Article
dc.source.journaltitleNature ecology and evolution
dc.source.volume2
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/rti_pubs/38
dc.identifier.contextkey12515846
html.description.abstract<p>In animals, small RNA molecules termed PIWI-interacting RNAs (piRNAs) silence transposable elements (TEs), protecting the germline from genomic instability and mutation. piRNAs have been detected in the soma in a few animals, but these are believed to be specific adaptations of individual species. Here, we report that somatic piRNAs were probably present in the ancestral arthropod more than 500 million years ago. Analysis of 20 species across the arthropod phylum suggests that somatic piRNAs targeting TEs and messenger RNAs are common among arthropods. The presence of an RNA-dependent RNA polymerase in chelicerates (horseshoe crabs, spiders and scorpions) suggests that arthropods originally used a plant-like RNA interference mechanism to silence TEs. Our results call into question the view that the ancestral role of the piRNA pathway was to protect the germline and demonstrate that small RNA silencing pathways have been repurposed for both somatic and germline functions throughout arthropod evolution.</p>
dc.identifier.submissionpathrti_pubs/38
dc.contributor.departmentRNA Therapeutics Institute
dc.source.pages174-181


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