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    Inhibition of CRISPR-Cas systems by mobile genetic elements

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    Authors
    Sontheimer, Erik J.
    Davidson, Alan R.
    UMass Chan Affiliations
    RNA Therapeutics Institute
    Document Type
    Journal Article
    Publication Date
    2017-06-01
    Keywords
    Biochemistry, Biophysics, and Structural Biology
    Genetics and Genomics
    Immunity
    Microbiology
    Therapeutics
    
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737815/
    Abstract
    Clustered, regularly interspaced, short, palindromic repeats (CRISPR) loci, together with their CRISPR-associated (Cas) proteins, provide bacteria and archaea with adaptive immunity against invasion by bacteriophages, plasmids, and other mobile genetic elements. These host defenses impart selective pressure on phages and mobile elements to evolve countermeasures against CRISPR immunity. As a consequence of this pressure, phages and mobile elements have evolved 'anti-CRISPR' proteins that function as direct inhibitors of diverse CRISPR-Cas effector complexes. Some of these CRISPR-Cas complexes can be deployed as genome engineering platforms, and anti-CRISPRs could therefore be useful in exerting spatial, temporal, or conditional control over genome editing and related applications. Here we describe the discovery of anti-CRISPRs, the range of CRISPR-Cas systems that they inhibit, their mechanisms of action, and their potential utility in biotechnology.
    Source

    Curr Opin Microbiol. 2017 Jun;37:120-127. doi: 10.1016/j.mib.2017.06.003. Epub 2017 Jun 29. Link to article on publisher's site

    DOI
    10.1016/j.mib.2017.06.003
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/48829
    PubMed ID
    28668720
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1016/j.mib.2017.06.003
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