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UMass Chan Affiliations
RNA Therapeutics InstituteDocument Type
Journal ArticlePublication Date
2017-06-01Keywords
Biochemistry, Biophysics, and Structural BiologyGenetics and Genomics
Immunity
Microbiology
Therapeutics
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Show full item recordAbstract
Clustered, regularly interspaced, short, palindromic repeats (CRISPR) loci, together with their CRISPR-associated (Cas) proteins, provide bacteria and archaea with adaptive immunity against invasion by bacteriophages, plasmids, and other mobile genetic elements. These host defenses impart selective pressure on phages and mobile elements to evolve countermeasures against CRISPR immunity. As a consequence of this pressure, phages and mobile elements have evolved 'anti-CRISPR' proteins that function as direct inhibitors of diverse CRISPR-Cas effector complexes. Some of these CRISPR-Cas complexes can be deployed as genome engineering platforms, and anti-CRISPRs could therefore be useful in exerting spatial, temporal, or conditional control over genome editing and related applications. Here we describe the discovery of anti-CRISPRs, the range of CRISPR-Cas systems that they inhibit, their mechanisms of action, and their potential utility in biotechnology.Source
Curr Opin Microbiol. 2017 Jun;37:120-127. doi: 10.1016/j.mib.2017.06.003. Epub 2017 Jun 29. Link to article on publisher's site
DOI
10.1016/j.mib.2017.06.003Permanent Link to this Item
http://hdl.handle.net/20.500.14038/48829PubMed ID
28668720Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/j.mib.2017.06.003