Deconstructing transport-distribution reconstruction in the nuclear-pore complex
UMass Chan AffiliationsGraduate School of Biomedical Sciences
RNA Therapeutics Institute
Document TypeLetter to the Editor
MetadataShow full item record
AbstractNuclear-pore complexes (NPCs) span the nuclear envelope and mediate bidirectional transport between the nucleus and cytoplasm. Macromolecules (>40 kDa) require transport receptors to transit the NPC efficiently, whereas smaller molecules diffuse through the NPC passively. The mechanism through which the semipermeable barrier at the center of the NPC regulates selective transport is unknown. Aiming to elucidate this mechanism, Yang and colleagues have investigated spatial cargo distribution within the NPC2 by using single-point edge-excitation subdiffraction (SPEED) microscopy.
Nat Struct Mol Biol. 2018 Dec;25(12):1061-1062. doi: 10.1038/s41594-018-0161-2. Epub 2018 Dec 5. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/48845