Document Type
Journal ArticlePublication Date
2007-02-18Keywords
AnimalsCell Differentiation
Growth Cones
Humans
Nerve Growth Factors
Nerve Regeneration
Neuroglia
Olfactory Pathways
Olfactory Receptor Neurons
Cell Biology
Metadata
Show full item recordAbstract
The olfactory system is a remarkable model for investigating the factors that influence the guidance of sensory axon populations to specific targets in the CNS. Since the initial discovery of the vast odorant receptor (ORs) gene family in rodents and the subsequent finding that these molecules directly influence targeting, several additional olfactory axon guidance cues have been identified. Two of these, ephrins and semaphorins, have well-established functions in patterning axon connections in other systems. In addition, lactosamine-containing glycans are also required for proper targeting and maintenance of olfactory axons, and may also function in other sensory regions. It is now apparent that these and likely other additional molecules are required along with ORs to orchestrate the complex pattern of convergence and divergence that is unique to the olfactory system.Source
J Cell Physiol. 2007 Feb;210(2):290-7. Link to article on publisher's siteDOI
10.1002/jcp.20888Permanent Link to this Item
http://hdl.handle.net/20.500.14038/48925PubMed ID
17111357Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1002/jcp.20888