Astrocytes interact intimately with degenerating motor neurons in mouse amyotrophic lateral sclerosis (ALS)
UMass Chan AffiliationsNeuroscience Program
Department of Cell Biology
Department of Pharmacology and Molecular Toxicology
Department of Psychiatry
Document TypeJournal Article
KeywordsAmyotrophic Lateral Sclerosis
Image Processing, Computer-Assisted
Nervous System Diseases
Neuroscience and Neurobiology
MetadataShow full item record
AbstractAstrocytic proliferation and hypertrophy (astrogliosis) are associated with neuronal injury. However, neither the temporal nor the spatial relationship between astrocytes and injured neurons is clear, especially in neurodegenerative diseases. We investigated these questions in a mouse amyotrophic lateral sclerosis (ALS) model. The initial increase in astrogliosis coincided with the onset of clinical disease and massive mitochondrial vacuolation in motor neurons. After disease onset, astrogliosis increased further in parallel with the number of degenerating motor neurons. Examination of individual astrocytes by three-dimensional reconstruction revealed that astrocytes extended their processes toward, wrapped around, and sometimes penetrated vacuoles derived from neuronal mitochondria. These results show a close temporal correlation between the onset of neuronal degeneration and the beginning of astrogliosis in this neurodegenerative disease and reveal a novel spatial relationship that is consistent with the view that astrocytes play an active role in the neuronal degeneration process.
SourceGlia. 1999 Dec;28(3):215-24. DOI: 10.1002/(SICI)1098-1136(199912)28:3<215::AID-GLIA5>3.0.CO;2-C Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/49229
Medical student John B. Levine participated in this study as part of the Senior Scholars research program at the University of Massachusetts Medical School.
Related ResourcesLink to Article in PubMed