Show simple item record

dc.contributor.authorLevine, John B.
dc.contributor.authorKong, Jiming
dc.contributor.authorNadler, Mark
dc.contributor.authorXu, Zuoshang
dc.date2022-08-11T08:10:55.000
dc.date.accessioned2022-08-23T17:24:37Z
dc.date.available2022-08-23T17:24:37Z
dc.date.issued1999-11-11
dc.date.submitted2015-02-13
dc.identifier.citationGlia. 1999 Dec;28(3):215-24. DOI: 10.1002/(SICI)1098-1136(199912)28:3<215::AID-GLIA5>3.0.CO;2-C <a href="http://dx.doi.org/10.1002/(SICI)1098-1136(199912)28:3<215::AID-GLIA5>3.0.CO;2-C">Link to article on publisher's site</a>
dc.identifier.issn0894-1491 (Linking)
dc.identifier.doi10.1002/(SICI)1098-1136(199912)28:3<215::AID-GLIA5>3.0.CO;2-C
dc.identifier.pmid10559780
dc.identifier.urihttp://hdl.handle.net/20.500.14038/49229
dc.description<p>Medical student John B. Levine participated in this study as part of the Senior Scholars research program at the University of Massachusetts Medical School.</p>
dc.description.abstractAstrocytic proliferation and hypertrophy (astrogliosis) are associated with neuronal injury. However, neither the temporal nor the spatial relationship between astrocytes and injured neurons is clear, especially in neurodegenerative diseases. We investigated these questions in a mouse amyotrophic lateral sclerosis (ALS) model. The initial increase in astrogliosis coincided with the onset of clinical disease and massive mitochondrial vacuolation in motor neurons. After disease onset, astrogliosis increased further in parallel with the number of degenerating motor neurons. Examination of individual astrocytes by three-dimensional reconstruction revealed that astrocytes extended their processes toward, wrapped around, and sometimes penetrated vacuoles derived from neuronal mitochondria. These results show a close temporal correlation between the onset of neuronal degeneration and the beginning of astrogliosis in this neurodegenerative disease and reveal a novel spatial relationship that is consistent with the view that astrocytes play an active role in the neuronal degeneration process.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=10559780&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1002/(SICI)1098-1136(199912)28:3<215::AID-GLIA5>3.0.CO;2-C
dc.subjectAmyotrophic Lateral Sclerosis
dc.subjectAnimals
dc.subjectAstrocytes
dc.subjectGliosis
dc.subjectHumans
dc.subjectImage Processing, Computer-Assisted
dc.subjectMice
dc.subjectMice, Transgenic
dc.subjectMitochondria
dc.subjectMotor Neurons
dc.subjectMutation
dc.subject*Nerve Degeneration
dc.subjectReference Values
dc.subjectSuperoxide Dismutase
dc.subjectVacuoles
dc.subjectCell Biology
dc.subjectNervous System Diseases
dc.subjectNeurology
dc.subjectNeuroscience and Neurobiology
dc.subjectPsychiatry
dc.titleAstrocytes interact intimately with degenerating motor neurons in mouse amyotrophic lateral sclerosis (ALS)
dc.typeJournal Article
dc.source.journaltitleGlia
dc.source.volume28
dc.source.issue3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/ssp/169
dc.identifier.contextkey6652110
html.description.abstract<p>Astrocytic proliferation and hypertrophy (astrogliosis) are associated with neuronal injury. However, neither the temporal nor the spatial relationship between astrocytes and injured neurons is clear, especially in neurodegenerative diseases. We investigated these questions in a mouse amyotrophic lateral sclerosis (ALS) model. The initial increase in astrogliosis coincided with the onset of clinical disease and massive mitochondrial vacuolation in motor neurons. After disease onset, astrogliosis increased further in parallel with the number of degenerating motor neurons. Examination of individual astrocytes by three-dimensional reconstruction revealed that astrocytes extended their processes toward, wrapped around, and sometimes penetrated vacuoles derived from neuronal mitochondria. These results show a close temporal correlation between the onset of neuronal degeneration and the beginning of astrogliosis in this neurodegenerative disease and reveal a novel spatial relationship that is consistent with the view that astrocytes play an active role in the neuronal degeneration process.</p>
dc.identifier.submissionpathssp/169
dc.contributor.departmentNeuroscience Program
dc.contributor.departmentDepartment of Cell Biology
dc.contributor.departmentDepartment of Pharmacology and Molecular Toxicology
dc.contributor.departmentDepartment of Psychiatry
dc.source.pages215-24


This item appears in the following Collection(s)

Show simple item record