Reclassification of a tubal leiomyosarcoma as an eGIST by molecular evaluation of c-KIT
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Faculty Advisor
Michael V. SeidenUMass Chan Affiliations
School of MedicineDocument Type
Journal ArticlePublication Date
2006-05-01Keywords
Base SequenceDiagnosis, Differential
Fallopian Tube Neoplasms
Female
Gastrointestinal Stromal Tumors
Humans
Leiomyosarcoma
Middle Aged
Molecular Sequence Data
Proto-Oncogene Proteins c-kit
Female Urogenital Diseases and Pregnancy Complications
Neoplasms
Obstetrics and Gynecology
Oncology
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BACKGROUND: Extragastrointestinal stromal tumors (eGISTs) are rare mesenchymal-derived tumors arising outside of the GI tract. eGISTs are often histologically confused with leiomyosarcoma. Distinction between eGIST and leiomyosarcoma is critical because of the unique responsiveness of eGISTs to the molecularly targeted agent imatinib. CASE: A woman presented with a history of tubal spindle cell tumor that was initially diagnosed and treated as a leiomyosarcoma. Because of minimal response to sarcoma directed chemotherapy, the possibility that the tumor was in fact an eGIST was investigated and supported by immunohistochemical and mutational analyses of the c-Kit receptor tyrosine kinase. The patient currently has stable disease control on imatinib for the last 18 months. CONCLUSIONS: The possibility of eGIST should be considered in the differential diagnosis of tumors with a spindle cell morphology in the gynecologic tract especially when involving the ovary, fallopian tube, or uterine serosa.Source
Gynecol Oncol. 2006 May;101(2):363-6. Epub 2006 Jan 24. Link to article on publisher's siteDOI
10.1016/j.ygyno.2005.12.022Permanent Link to this Item
http://hdl.handle.net/20.500.14038/49235PubMed ID
16439005Notes
Medical student Steven Solano initially participated in this study as part of the Senior Scholars research program at the University of Massachusetts Medical School.
Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.ygyno.2005.12.022