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    Magnetic resonance imaging of tissue and vascular layers in the cat retina

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    Authors
    Shen, Qiang
    Cheng, Haiying
    Pardue, Machelle T.
    Chang, Thomas F.
    Nair, Govind
    Vo, Van Toi
    Shonat, Ross D.
    Duong, Timothy Q.
    Faculty Advisor
    Timothy Q. Duong
    UMass Chan Affiliations
    School of Medicine
    Document Type
    Journal Article
    Publication Date
    2006-04-01
    Keywords
    Animals
    Cats
    Contrast Media
    Diffusion Magnetic Resonance Imaging
    Female
    Gadolinium DTPA
    Image Processing, Computer-Assisted
    Magnetic Resonance Imaging
    Retina
    Subtraction Technique
    Radiology
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    Link to Full Text
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949960/
    Abstract
    PURPOSE: To report the visual resolution of multiple cell and vascular "layers" in the cat retina using MRI. MATERIALS AND METHODS: T2- and diffusion-weighted MRI at 4.7 Tesla was performed. Layer-specific thickness, T2, spin density, apparent diffusion coefficient perpendicular (ADC(perpendicular)) and parallel (ADC(parallel)) to the retinal surface were tabulated. T1-weighted MRI was acquired before and after intravenous administration of Gd-DTPA and subtraction images were obtained. Histology was performed for validation. RESULTS: Three distinct "layers" were observed. The inner strip nearest to the vitreous (exhibiting large T2, ADC, spin density with Gd-DTPA enhancement) overlapped the ganglion cell layer, bipolar cell layer, and the embedded retinal vascular layer. The middle strip (exhibiting small T2, ADC, spin density without Gd-DTPA enhancement) overlapped the photoreceptor cell layer and the inner and outer segments. The outer strip (exhibiting large T2, ADC, spin density with Gd-DTPA enhancement) overlapped the tapetum and choroidal vascular layer. T2, spin density, ADC(perpendicular) and ADC(parallel) of different "layers" were tabulated. The inner strip was slightly thicker than the other two strips. The total thickness, including neural and nonneural retina, was 358 +/- 13 microm (N = 6) by MRI and 319 +/- 77 microm (N = 5) by histology. CONCLUSION: MRI provides a noninvasive tool to study the retina with laminar specificity without depth limitation.
    Source
    J Magn Reson Imaging. 2006 Apr;23(4):465-72. Link to article on publisher's site
    DOI
    10.1002/jmri.20549
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/49236
    PubMed ID
    16523482
    Notes

    Medical student Thomas F. Chang participated in this study as part of the Senior Scholars research program at the University of Massachusetts Medical School.

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    Link to Article in PubMed
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    10.1002/jmri.20549
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