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dc.contributor.advisorTimothy Q. Duong
dc.contributor.authorShen, Qiang
dc.contributor.authorCheng, Haiying
dc.contributor.authorPardue, Machelle T.
dc.contributor.authorChang, Thomas F.
dc.contributor.authorNair, Govind
dc.contributor.authorVo, Van Toi
dc.contributor.authorShonat, Ross D.
dc.contributor.authorDuong, Timothy Q.
dc.date2022-08-11T08:10:55.000
dc.date.accessioned2022-08-23T17:24:39Z
dc.date.available2022-08-23T17:24:39Z
dc.date.issued2006-04-01
dc.date.submitted2015-02-13
dc.identifier.citationJ Magn Reson Imaging. 2006 Apr;23(4):465-72. <a href="http://dx.doi.org/10.1002/jmri.20549">Link to article on publisher's site</a>
dc.identifier.issn1053-1807 (Linking)
dc.identifier.doi10.1002/jmri.20549
dc.identifier.pmid16523482
dc.identifier.urihttp://hdl.handle.net/20.500.14038/49236
dc.description<p>Medical student Thomas F. Chang participated in this study as part of the Senior Scholars research program at the University of Massachusetts Medical School.</p>
dc.description.abstractPURPOSE: To report the visual resolution of multiple cell and vascular "layers" in the cat retina using MRI. MATERIALS AND METHODS: T2- and diffusion-weighted MRI at 4.7 Tesla was performed. Layer-specific thickness, T2, spin density, apparent diffusion coefficient perpendicular (ADC(perpendicular)) and parallel (ADC(parallel)) to the retinal surface were tabulated. T1-weighted MRI was acquired before and after intravenous administration of Gd-DTPA and subtraction images were obtained. Histology was performed for validation. RESULTS: Three distinct "layers" were observed. The inner strip nearest to the vitreous (exhibiting large T2, ADC, spin density with Gd-DTPA enhancement) overlapped the ganglion cell layer, bipolar cell layer, and the embedded retinal vascular layer. The middle strip (exhibiting small T2, ADC, spin density without Gd-DTPA enhancement) overlapped the photoreceptor cell layer and the inner and outer segments. The outer strip (exhibiting large T2, ADC, spin density with Gd-DTPA enhancement) overlapped the tapetum and choroidal vascular layer. T2, spin density, ADC(perpendicular) and ADC(parallel) of different "layers" were tabulated. The inner strip was slightly thicker than the other two strips. The total thickness, including neural and nonneural retina, was 358 +/- 13 microm (N = 6) by MRI and 319 +/- 77 microm (N = 5) by histology. CONCLUSION: MRI provides a noninvasive tool to study the retina with laminar specificity without depth limitation.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=16523482&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949960/
dc.subjectAnimals
dc.subjectCats
dc.subjectContrast Media
dc.subjectDiffusion Magnetic Resonance Imaging
dc.subjectFemale
dc.subjectGadolinium DTPA
dc.subjectImage Processing, Computer-Assisted
dc.subjectMagnetic Resonance Imaging
dc.subjectRetina
dc.subjectSubtraction Technique
dc.subjectRadiology
dc.titleMagnetic resonance imaging of tissue and vascular layers in the cat retina
dc.typeJournal Article
dc.source.journaltitleJournal of magnetic resonance imaging : JMRI
dc.source.volume23
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/ssp/181
dc.identifier.contextkey6652122
html.description.abstract<p>PURPOSE: To report the visual resolution of multiple cell and vascular "layers" in the cat retina using MRI.</p> <p>MATERIALS AND METHODS: T2- and diffusion-weighted MRI at 4.7 Tesla was performed. Layer-specific thickness, T2, spin density, apparent diffusion coefficient perpendicular (ADC(perpendicular)) and parallel (ADC(parallel)) to the retinal surface were tabulated. T1-weighted MRI was acquired before and after intravenous administration of Gd-DTPA and subtraction images were obtained. Histology was performed for validation.</p> <p>RESULTS: Three distinct "layers" were observed. The inner strip nearest to the vitreous (exhibiting large T2, ADC, spin density with Gd-DTPA enhancement) overlapped the ganglion cell layer, bipolar cell layer, and the embedded retinal vascular layer. The middle strip (exhibiting small T2, ADC, spin density without Gd-DTPA enhancement) overlapped the photoreceptor cell layer and the inner and outer segments. The outer strip (exhibiting large T2, ADC, spin density with Gd-DTPA enhancement) overlapped the tapetum and choroidal vascular layer. T2, spin density, ADC(perpendicular) and ADC(parallel) of different "layers" were tabulated. The inner strip was slightly thicker than the other two strips. The total thickness, including neural and nonneural retina, was 358 +/- 13 microm (N = 6) by MRI and 319 +/- 77 microm (N = 5) by histology.</p> <p>CONCLUSION: MRI provides a noninvasive tool to study the retina with laminar specificity without depth limitation.</p>
dc.identifier.submissionpathssp/181
dc.contributor.departmentSchool of Medicine
dc.source.pages465-72


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