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    Low serum zinc levels in an endemic area of visceral leishmaniasis in Bihar, India

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    Authors
    Mishra, Jyotsna
    Carpenter, Stephen
    Singh, Sarman
    Faculty Advisor
    Sanman Singh in India; Mick Godkin in Department of Family Medicine and Community Health
    UMass Chan Affiliations
    School of Medicine
    Document Type
    Journal Article
    Publication Date
    2010-06-01
    Keywords
    Adult
    Animals
    Child
    Female
    Humans
    India
    Leishmania
    Leishmaniasis, Visceral
    Male
    Poverty
    Rural Population
    Urban Population
    Young Adult
    Zinc
    Bihar socio-economic status
    epidemiology
    immune system
    malnourishment
    visceral leishmaniasis
    zinc deficiency
    Clinical Epidemiology
    Epidemiology
    Nutritional and Metabolic Diseases
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    Link to Full Text
    http://www.ijmr.org.in/downloadpdf.asp?issn=0971-5916;year=2010;volume=131;issue=6;spage=793;epage=798;aulast=Mishra;type=2
    Abstract
    BACKGROUND and OBJECTIVES: India carries approximately 50 per cent of the global burden of visceral leishmaniasis and majority of patients from the poor, rural communities of Bihar State. Zinc is an essential trace element and its relevance for proper functioning of the entire immune system is already well documented. Though low serum zinc levels have been reported in many parasitic diseases, limited information is available regarding zinc status in human leishmaniasis. We investigated to define the relationship between zinc level in visceral leishmaniasis (VL) patients in endemic and non-endemic regions. METHODS: Venous blood was collected from 88 patients, 16 parasitologically confirmed VL, 35 healthy controls from endemic area (Bihar) and 37 healthy urban controls from non-endemic area, Delhi. In all the three groups, levels of serum albumin, total protein (markers of nutritional status) and zinc were estimated by colorimetric methods. RESULTS: Serum zinc levels were found to be significantly lower (P<0.001) in VL patients than non-endemic controls. The serum zinc levels in VL endemic controls were also significantly lower (P < 0.001) than non- endemic controls, but these values were not statistically significantly different from VL patients. However, all samples from Bihar (VL patients and controls) had lower serum zinc levels than non-endemic controls from Delhi. INTERPRETATION and CONCLUSION: Low serum Zn levels, in healthy subjects from Bihar and more significantly in VL patients of this region, are possibly associated with vulnerability and endemicity of visceral leishmaniasis in the region. Further studies need to be done to assess the role of oral zinc supplementation in better management and prevention of VL, particularly in endemic areas.
    Source
    Indian J Med Res. 2010 Jun;131:793-8. Link to article on publisher's website
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/49238
    PubMed ID
    20571168
    Notes
    Medical student Stephen Carpenter participated in this study as part of the Senior Scholars research program at the University of Massachusetts Medical School.
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    Link to Article in PubMed
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    T.H. Chan School of Medicine Student Publications
    Senior Scholars Program

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