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dc.contributor.advisorSanman Singh in India; Mick Godkin in Department of Family Medicine and Community Health
dc.contributor.authorMishra, Jyotsna
dc.contributor.authorCarpenter, Stephen
dc.contributor.authorSingh, Sarman
dc.date2022-08-11T08:10:55.000
dc.date.accessioned2022-08-23T17:24:39Z
dc.date.available2022-08-23T17:24:39Z
dc.date.issued2010-06-01
dc.date.submitted2015-02-13
dc.identifier.citationIndian J Med Res. 2010 Jun;131:793-8. <a href="http://www.ijmr.org.in/downloadpdf.asp?issn=0971-5916;year=2010;volume=131;issue=6;spage=793;epage=798;aulast=Mishra;type=2">Link to article on publisher's website</a>
dc.identifier.issn0971-5916 (Linking)
dc.identifier.pmid20571168
dc.identifier.urihttp://hdl.handle.net/20.500.14038/49238
dc.descriptionMedical student Stephen Carpenter participated in this study as part of the Senior Scholars research program at the University of Massachusetts Medical School.
dc.description.abstractBACKGROUND and OBJECTIVES: India carries approximately 50 per cent of the global burden of visceral leishmaniasis and majority of patients from the poor, rural communities of Bihar State. Zinc is an essential trace element and its relevance for proper functioning of the entire immune system is already well documented. Though low serum zinc levels have been reported in many parasitic diseases, limited information is available regarding zinc status in human leishmaniasis. We investigated to define the relationship between zinc level in visceral leishmaniasis (VL) patients in endemic and non-endemic regions. METHODS: Venous blood was collected from 88 patients, 16 parasitologically confirmed VL, 35 healthy controls from endemic area (Bihar) and 37 healthy urban controls from non-endemic area, Delhi. In all the three groups, levels of serum albumin, total protein (markers of nutritional status) and zinc were estimated by colorimetric methods. RESULTS: Serum zinc levels were found to be significantly lower (P<0.001) in VL patients than non-endemic controls. The serum zinc levels in VL endemic controls were also significantly lower (P < 0.001) than non- endemic controls, but these values were not statistically significantly different from VL patients. However, all samples from Bihar (VL patients and controls) had lower serum zinc levels than non-endemic controls from Delhi. INTERPRETATION and CONCLUSION: Low serum Zn levels, in healthy subjects from Bihar and more significantly in VL patients of this region, are possibly associated with vulnerability and endemicity of visceral leishmaniasis in the region. Further studies need to be done to assess the role of oral zinc supplementation in better management and prevention of VL, particularly in endemic areas.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=20571168&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://www.ijmr.org.in/downloadpdf.asp?issn=0971-5916;year=2010;volume=131;issue=6;spage=793;epage=798;aulast=Mishra;type=2
dc.subjectAdult
dc.subjectAnimals
dc.subjectChild
dc.subjectFemale
dc.subjectHumans
dc.subjectIndia
dc.subjectLeishmania
dc.subjectLeishmaniasis, Visceral
dc.subjectMale
dc.subjectPoverty
dc.subjectRural Population
dc.subjectUrban Population
dc.subjectYoung Adult
dc.subjectZinc
dc.subjectBihar socio-economic status
dc.subjectepidemiology
dc.subjectimmune system
dc.subjectmalnourishment
dc.subjectvisceral leishmaniasis
dc.subjectzinc deficiency
dc.subjectClinical Epidemiology
dc.subjectEpidemiology
dc.subjectNutritional and Metabolic Diseases
dc.titleLow serum zinc levels in an endemic area of visceral leishmaniasis in Bihar, India
dc.typeJournal Article
dc.source.journaltitleThe Indian journal of medical research
dc.source.volume131
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/ssp/183
dc.identifier.contextkey6652125
html.description.abstract<p>BACKGROUND and OBJECTIVES: India carries approximately 50 per cent of the global burden of visceral leishmaniasis and majority of patients from the poor, rural communities of Bihar State. Zinc is an essential trace element and its relevance for proper functioning of the entire immune system is already well documented. Though low serum zinc levels have been reported in many parasitic diseases, limited information is available regarding zinc status in human leishmaniasis. We investigated to define the relationship between zinc level in visceral leishmaniasis (VL) patients in endemic and non-endemic regions. METHODS: Venous blood was collected from 88 patients, 16 parasitologically confirmed VL, 35 healthy controls from endemic area (Bihar) and 37 healthy urban controls from non-endemic area, Delhi. In all the three groups, levels of serum albumin, total protein (markers of nutritional status) and zinc were estimated by colorimetric methods. RESULTS: Serum zinc levels were found to be significantly lower (P<0.001) in VL patients than non-endemic controls. The serum zinc levels in VL endemic controls were also significantly lower (P < 0.001) than non- endemic controls, but these values were not statistically significantly different from VL patients. However, all samples from Bihar (VL patients and controls) had lower serum zinc levels than non-endemic controls from Delhi. INTERPRETATION and CONCLUSION: Low serum Zn levels, in healthy subjects from Bihar and more significantly in VL patients of this region, are possibly associated with vulnerability and endemicity of visceral leishmaniasis in the region. Further studies need to be done to assess the role of oral zinc supplementation in better management and prevention of VL, particularly in endemic areas.</p>
dc.identifier.submissionpathssp/183
dc.contributor.departmentSchool of Medicine
dc.source.pages793-8


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