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dc.contributor.advisorTiffany A. Moore Simas; Silvia Corvera
dc.contributor.authorSert, Aylin
dc.contributor.authorLeung, Katherine
dc.contributor.authorWaring, Molly E.
dc.contributor.authorRojas-Rodriguez, Raziel
dc.contributor.authorCorvera, Silvia
dc.contributor.authorMoore Simas, Tiffany A.
dc.date2022-08-11T08:10:55.000
dc.date.accessioned2022-08-23T17:24:54Z
dc.date.available2022-08-23T17:24:54Z
dc.date.issued2016-04-27
dc.date.submitted2016-04-29
dc.identifier.doi10.13028/9xbg-es93
dc.identifier.urihttp://hdl.handle.net/20.500.14038/49293
dc.description<p>Aylin Sert participated in this study as a medical student as part of the Senior Scholars research program at the University of Massachusetts Medical School. This poster was presented on Senior Scholars Program Poster Presentation Day at the University of Massachusetts Medical School, Worcester, MA, on April 27, 2016.</p> <p>Work funded by the Worcester Foundation for Biomedical Research. Support for Dr. Waring provided by NIH grant KL2TR000160.</p>
dc.description.abstractBackground: Gestational diabetes (GDM) is a common pregnancy complication with significant cardiometabolic consequences for mothers and offspring. Previous research from our group suggests that adipose tissue IGFBP-5 and its unique metalloprotease PAPP-A (Pregnancy Associated Plasma Protein-A) may play mechanistic roles in GDM development by regulating functional IGF-1 levels and lipid storage and metabolism. Aim: To examine the relationship between circulating PAPP-A levels and GDM development. We hypothesized that high first trimester PAPP-A levels would be associated with decreased GDM risk. Methods: A retrospective cohort of women delivering singleton gestations at UMass Memorial Healthcare (2009, 2010, 2014, 2015) was assembled by abstracting electronic medical records. PAPP-A was measured in first trimester (11-14 weeks), and reported as quartiles of multiples of the mean (MoM) based on gestational age and adjusted for maternal weight and race/ethnicity. GDM diagnosis based on standard 2-step protocol (~24-28 weeks; failed 50g 1hr glucola screen then ≥2 abnormal values per Carpenter-Coustan criteria on 100g 3hr glucose tolerance test). Crude and multivariable-adjusted logistic regression models estimated the association between PAPP-A MoM quartiles and GDM. Results: Women (N=1,251) were 29.7 (SD:5.7) years old and 12.5 (SD:0.6) weeks gestation at PAPP-A measurement. 7.6% (n=95) developed GDM. Median PAPP-A MoM were 0.7 (inter-quartile range [IQR]=0.5-1.0) among women with GDM and 0.9 (IQR=0.6-1.3) among controls; 39% versus 23% were in the 1st quartile, respectively. After adjusting for pre-pregnancy body mass index, nuchal translucency, crown rump length, smoking status, and parity, women with PAPP-A MoM in 2nd, 3rd, and 4th quartiles had 52% (OR=0.48, 95%CI=0.26-0.88), 45% (OR=0.55, 95%CI=0.30-0.99) and 73% (OR=0.27, 95%CI=0.13-0.53) lower odds of GDM compared to women in the 1st quartile. Conclusion: Higher PAPP-A MoM levels were associated with lower GDM risk. Future studies will assess whether higher PAPP-A levels are associated with enhanced IGF-1 signaling and improved pregnancy metabolic homeostasis.
dc.language.isoen_US
dc.rightsCopyright is held by the author(s), with all rights reserved.
dc.subjectPregnancy Associated Plasma Protein
dc.subjectPAPP-A
dc.subjectGestional diabetes mellitus
dc.subjectIGFBP-5
dc.subjectIGF-1
dc.subjectClinical Epidemiology
dc.subjectEndocrinology, Diabetes, and Metabolism
dc.subjectFemale Urogenital Diseases and Pregnancy Complications
dc.subjectMaternal and Child Health
dc.subjectObstetrics and Gynecology
dc.subjectWomen's Health
dc.titleAssociation between First Trimester Pregnancy Associated Plasma Protein–A (PAPP-A) and Gestational Diabetes Mellitus Development
dc.typePoster
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1236&amp;context=ssp&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/ssp/235
dc.identifier.contextkey8540513
refterms.dateFOA2022-08-25T04:48:29Z
html.description.abstract<p><strong>Background:</strong> Gestational diabetes (GDM) is a common pregnancy complication with significant cardiometabolic consequences for mothers and offspring. Previous research from our group suggests that adipose tissue IGFBP-5 and its unique metalloprotease PAPP-A (<strong>P</strong>regnancy <strong>A</strong>ssociated <strong>P</strong>lasma <strong>P</strong>rotein-A) may play mechanistic roles in GDM development by regulating functional IGF-1 levels and lipid storage and metabolism.</p> <p><strong>Aim:</strong> To examine the relationship between circulating PAPP-A levels and GDM development. We hypothesized that high first trimester PAPP-A levels would be associated with decreased GDM risk.</p> <p><strong>Methods:</strong> A retrospective cohort of women delivering singleton gestations at UMass Memorial Healthcare (2009, 2010, 2014, 2015) was assembled by abstracting electronic medical records. PAPP-A was measured in first trimester (11-14 weeks), and reported as quartiles of multiples of the mean (MoM) based on gestational age and adjusted for maternal weight and race/ethnicity. GDM diagnosis based on standard 2-step protocol (~24-28 weeks; failed 50g 1hr glucola screen then ≥2 abnormal values per Carpenter-Coustan criteria on 100g 3hr glucose tolerance test). Crude and multivariable-adjusted logistic regression models estimated the association between PAPP-A MoM quartiles and GDM.</p> <p><strong>Results: </strong>Women (N=1,251) were 29.7 (SD:5.7) years old and 12.5 (SD:0.6) weeks gestation at PAPP-A measurement. 7.6% (n=95) developed GDM. Median PAPP-A MoM were 0.7 (inter-quartile range [IQR]=0.5-1.0) among women with GDM and 0.9 (IQR=0.6-1.3) among controls; 39% versus 23% were in the 1<sup>st</sup> quartile, respectively. After adjusting for pre-pregnancy body mass index, nuchal translucency, crown rump length, smoking status, and parity, women with PAPP-A MoM in 2<sup>nd</sup>, 3<sup>rd</sup>, and 4th quartiles had 52% (OR=0.48, 95%CI=0.26-0.88), 45% (OR=0.55, 95%CI=0.30-0.99) and 73% (OR=0.27, 95%CI=0.13-0.53) lower odds of GDM compared to women in the 1<sup>st</sup> quartile.</p> <p><strong>Conclusion: </strong>Higher PAPP-A MoM levels were associated with lower GDM risk. Future studies will assess whether higher PAPP-A levels are associated with enhanced IGF-1 signaling and improved pregnancy metabolic homeostasis.</p>
dc.identifier.submissionpathssp/235
dc.contributor.departmentDepartment of Pediatrics
dc.contributor.departmentProgram in Molecular Medicine
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.contributor.departmentDepartment of Obstetrics and Gynecology
dc.contributor.departmentSchool of Medicine, Clinical Translational Research Pathway
dc.contributor.departmentSenior Scholars Program


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