Outpatient beta-blockers and survival from sepsis: Results from a national cohort of Medicare beneficiaries
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AuthorsSinger, Kathleen E.
Collins, Courtney E.
Ayturk, M. Didem
Faculty AdvisorHeena Santry
UMass Chan AffiliationsSenior Scholars Program
School of Medicine
Department of Quantitative Health Sciences
Department of Surgery
Document TypeJournal Article
Bacterial Infections and Mycoses
Pathological Conditions, Signs and Symptoms
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AbstractBACKGROUND: Elderly Americans suffer increased mortality from sepsis. Given that beta-blockers have been shown to be cardioprotective in critical care, we investigated outpatient beta-blocker prescriptions and mortality among Medicare beneficiaries admitted for sepsis. METHODS: We queried a 5% random sample of Medicare beneficiaries for patients admitted with sepsis. We used in-hospital and outpatient prescription drug claims to compare in-hospital and 30-day mortality based on pre-admission beta-blocker prescription and class of beta-blocker prescribed using univariate tests of comparison and multivariable logistic regression models and another class of medications for control. RESULTS: Outpatient beta-blocker prescription was associated with a statistically significant decrease in in-hospital and 30-day mortality. In multivariable modeling, beta-blocker prescription was associated with 31% decrease in in-hospital mortality and 41% decrease in 30-day mortality. Both cardioselective and non-selective beta-blockers conferred mortality benefit. CONCLUSIONS: Our data suggests that there may be a role for preadmission beta-blockers in reducing sepsis-related mortality.
Am J Surg. 2017 Oct;214(4):577-582. doi: 10.1016/j.amjsurg.2017.06.007. Epub 2017 Jun 24. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/49324
Kathleen Singer participated in this study as a medical student as part of the Senior Scholars research program at the University of Massachusetts Medical School.