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dc.contributor.authorTripputi, P.
dc.contributor.authorEmanuel, B. S.
dc.contributor.authorCroce, Carlo M.
dc.contributor.authorGreen, Linda G.
dc.contributor.authorStein, Gary S.
dc.contributor.authorStein, Janet L.
dc.date2022-08-11T08:10:56.000
dc.date.accessioned2022-08-23T17:25:47Z
dc.date.available2022-08-23T17:25:47Z
dc.date.issued1986-05-01
dc.date.submitted2011-01-14
dc.identifier.citationProc Natl Acad Sci U S A. 1986 May;83(10):3185-8.
dc.identifier.issn0027-8424 (Linking)
dc.identifier.pmid3458175
dc.identifier.urihttp://hdl.handle.net/20.500.14038/49484
dc.description.abstractHistone genes were mapped to at least three human chromosomes by Southern blot analysis of DNAs from a series of mouse-human somatic cell hybrids (using 32P-labeled cloned human histone DNA as probes). Chromosome assignment was confirmed by in situ hybridization of radiolabeled histone gene probes (3H-labeled) to metaphase chromosomes. One human histone gene cluster (lambda HHG41) containing an H3 and H4 gene resides only on chromosome 1, whereas other clusters containing core (H3, H4, H2A, and H2B) alone (lambda HHG17) or core together with H1 histone genes (lambda HHG415) have been assigned to chromosomes 1, 6, and 12. These results suggest that the multigene family of histone coding sequences that reside in a series of clusters may be derived from a single cluster containing one each of the genes for the five principal classes of histone proteins. During the course of evolution, a set of events, probably involving reduplication, sequence modification, and recombination, resulted in the present pattern of human histone gene distribution among several chromosomes.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=3458175&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://www.pnas.org/content/83/10/3185.full.pdf+html
dc.subjectChromosome Mapping
dc.subjectChromosomes, Human, 1-3
dc.subjectChromosomes, Human, 6-12 and X
dc.subjectEvolution
dc.subjectGenes
dc.subjectHistones
dc.subjectHumans
dc.subjectHybrid Cells
dc.subjectCell Biology
dc.titleHuman histone genes map to multiple chromosomes
dc.typeJournal Article
dc.source.journaltitleProceedings of the National Academy of Sciences of the United States of America
dc.source.volume83
dc.source.issue10
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/stein/140
dc.identifier.contextkey1728445
html.description.abstract<p>Histone genes were mapped to at least three human chromosomes by Southern blot analysis of DNAs from a series of mouse-human somatic cell hybrids (using 32P-labeled cloned human histone DNA as probes). Chromosome assignment was confirmed by in situ hybridization of radiolabeled histone gene probes (3H-labeled) to metaphase chromosomes. One human histone gene cluster (lambda HHG41) containing an H3 and H4 gene resides only on chromosome 1, whereas other clusters containing core (H3, H4, H2A, and H2B) alone (lambda HHG17) or core together with H1 histone genes (lambda HHG415) have been assigned to chromosomes 1, 6, and 12. These results suggest that the multigene family of histone coding sequences that reside in a series of clusters may be derived from a single cluster containing one each of the genes for the five principal classes of histone proteins. During the course of evolution, a set of events, probably involving reduplication, sequence modification, and recombination, resulted in the present pattern of human histone gene distribution among several chromosomes.</p>
dc.identifier.submissionpathstein/140
dc.contributor.departmentDepartment of Cell Biology
dc.source.pages3185-8


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