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The effect of SV40 transformation on the chromosomal proteins of 3T3 mouse embryo fibroblasts

dc.contributor.authorKrause, M. O.
dc.contributor.authorNoonan, K. D.
dc.contributor.authorKleinsmith, Lewis J.
dc.contributor.authorStein, Gary S.
dc.date2022-08-11T08:10:56.000
dc.date.accessioned2022-08-23T17:25:58Z
dc.date.available2022-08-23T17:25:58Z
dc.date.issued1976-07-01
dc.date.submitted2011-01-14
dc.identifier.citationCell Differ. 1976 Jul;5(2):83-96.
dc.identifier.issn0045-6039 (Linking)
dc.identifier.pmid183894
dc.identifier.urihttp://hdl.handle.net/20.500.14038/49530
dc.description.abstractThe composition and metabolism of chromosomal proteins-histones and nonhistones chromosomal proteins-were examined in normal and SV40 transformed 3T3 mouse cells. Variations were observed, many of which were similar to those previously reported for normal and SV40 transformed W138 human diploid fibroblasts. The possible implications of these viral induced changes in the protein component of the genome for the phenotypic modifications which occur in transformed cells are discussed.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=183894&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/0045-6039(76)90002-6
dc.subjectAged
dc.subjectCell Line
dc.subject*Cell Transformation, Neoplastic
dc.subjectDNA Replication
dc.subjectElectrophoresis, Polyacrylamide Gel
dc.subjectHistones
dc.subjectHumans
dc.subjectInfant, Newborn
dc.subjectMolecular Weight
dc.subjectPhosphates
dc.subjectSimian virus 40
dc.subjectCell Biology
dc.titleThe effect of SV40 transformation on the chromosomal proteins of 3T3 mouse embryo fibroblasts
dc.typeJournal Article
dc.source.journaltitleCell differentiation
dc.source.volume5
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/stein/198
dc.identifier.contextkey1728505
html.description.abstract<p>The composition and metabolism of chromosomal proteins-histones and nonhistones chromosomal proteins-were examined in normal and SV40 transformed 3T3 mouse cells. Variations were observed, many of which were similar to those previously reported for normal and SV40 transformed W138 human diploid fibroblasts. The possible implications of these viral induced changes in the protein component of the genome for the phenotypic modifications which occur in transformed cells are discussed.</p>
dc.identifier.submissionpathstein/198
dc.contributor.departmentDepartment of Cell Biology
dc.source.pages83-96


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