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    An architectural genetic and epigenetic perspective

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    Authors
    Stein, Gary S.
    Stein, Janet L.
    Van Wijnen, Andre J.
    Zaidi, Sayyed K.
    Nickerson, Jeffrey A.
    Montecino, Martin A.
    Young, Daniel W.
    UMass Chan Affiliations
    Department of Cell Biology
    Document Type
    Journal Article
    Publication Date
    2011-04-25
    Keywords
    Epigenesis, Genetic
    Transcription Factors
    Intracellular Space
    Gene Expression Regulation
    Cell Biology
    
    Metadata
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    Link to Full Text
    http://dx.doi.org/10.1039/c0ib00103a
    Abstract
    The organization and intranuclear localization of nucleic acids and regulatory proteins contribute to both genetic and epigenetic parameters of biological control. Regulatory machinery in the cell nucleus is functionally compartmentalized in microenvironments (focally organized sites where regulatory factors reside) that provide threshold levels of factors required for transcription, replication, repair and cell survival. The common denominator for nuclear organization of regulatory machinery is that each component of control is architecturally configured and every component of control is embedded in architecturally organized networks that provide an infrastructure for integration and transduction of regulatory signals. It is realistic to anticipate emerging mechanisms that account for the organization and assembly of regulatory complexes within the cell nucleus can provide novel options for cancer diagnosis and therapy with maximal specificity, reduced toxicity and minimal off-target complications.
    Source
    Integr Biol (Camb). 2011 Apr;3(4):297-303. Epub 2010 Dec 24. Link to article on publisher's site
    DOI
    10.1039/c0ib00103a
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/49565
    PubMed ID
    21184003
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1039/c0ib00103a
    Scopus Count
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