Authors
Stein, Gary S.Stein, Janet L.
Van Wijnen, Andre J.
Zaidi, Sayyed K.
Nickerson, Jeffrey A.
Montecino, Martin A.
Young, Daniel W.
UMass Chan Affiliations
Department of Cell BiologyDocument Type
Journal ArticlePublication Date
2011-04-25Keywords
Epigenesis, GeneticTranscription Factors
Intracellular Space
Gene Expression Regulation
Cell Biology
Metadata
Show full item recordAbstract
The organization and intranuclear localization of nucleic acids and regulatory proteins contribute to both genetic and epigenetic parameters of biological control. Regulatory machinery in the cell nucleus is functionally compartmentalized in microenvironments (focally organized sites where regulatory factors reside) that provide threshold levels of factors required for transcription, replication, repair and cell survival. The common denominator for nuclear organization of regulatory machinery is that each component of control is architecturally configured and every component of control is embedded in architecturally organized networks that provide an infrastructure for integration and transduction of regulatory signals. It is realistic to anticipate emerging mechanisms that account for the organization and assembly of regulatory complexes within the cell nucleus can provide novel options for cancer diagnosis and therapy with maximal specificity, reduced toxicity and minimal off-target complications.Source
Integr Biol (Camb). 2011 Apr;3(4):297-303. Epub 2010 Dec 24. Link to article on publisher's siteDOI
10.1039/c0ib00103aPermanent Link to this Item
http://hdl.handle.net/20.500.14038/49565PubMed ID
21184003Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1039/c0ib00103a