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dc.contributor.authorStein, Gary S.
dc.contributor.authorVan Wijnen, Andre J.
dc.contributor.authorLian, Jane B.
dc.contributor.authorImbalzano, Anthony N.
dc.contributor.authorMontecino, Martin A.
dc.contributor.authorZaidi, Sayyed K.
dc.contributor.authorLian, Jane B.
dc.contributor.authorNickerson, Jeffrey A.
dc.contributor.authorStein, Janet L.
dc.date2022-08-11T08:10:57.000
dc.date.accessioned2022-08-23T17:26:07Z
dc.date.available2022-08-23T17:26:07Z
dc.date.issued2010-12-08
dc.date.submitted2011-02-23
dc.identifier.citationCrit Rev Eukaryot Gene Expr. 2010;20(2):149-55. <a href="http://www.begellhouse.com/journals/6dbf508d3b17c437,4755276625828a95,6260d12b618a7c4b.html">Link to article on publisher's website</a>
dc.identifier.issn1045-4403 (Linking)
dc.identifier.pmid21133844
dc.identifier.urihttp://hdl.handle.net/20.500.14038/49566
dc.description.abstractThe regulatory machinery that governs genetic and epigenetic control of gene expression for biological processes and cancer is organized in nuclear microenvironments. Strategic placement of transcription factors at target gene promoters in punctate microenvironments of interphase nuclei supports scaffolding of co- regulatory proteins and the convergence as well as integration of regulatory networks. The organization and localization of regulatory complexes within the nucleus can provide signatures that are linked to regulatory activity. Retention of transcription factors at gene loci in mitotic chromosomes contributes to epigenetic control of cell fate and lineage commitment, as well as to persistence of transformed and tumor phenotypes. Mechanistic understanding of the architectural assembly of regulatory machinery can serve as a basis for treating cancer with high specificity and minimal off-target effects.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=21133844&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://www.begellhouse.com/journals/6dbf508d3b17c437,4755276625828a95,6260d12b618a7c4b.html
dc.subjectEpigenesis, Genetic
dc.subjectTranscription Factors
dc.subjectIntracellular Space
dc.subjectGene Expression Regulation
dc.subjectCell Biology
dc.titleArchitectural genetic and epigenetic control of regulatory networks: compartmentalizing machinery for transcription and chromatin remodeling in nuclear microenvironments
dc.typeJournal Article
dc.source.journaltitleCritical reviews in eukaryotic gene expression
dc.source.volume20
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/stein/238
dc.identifier.contextkey1810218
html.description.abstract<p>The regulatory machinery that governs genetic and epigenetic control of gene expression for biological processes and cancer is organized in nuclear microenvironments. Strategic placement of transcription factors at target gene promoters in punctate microenvironments of interphase nuclei supports scaffolding of co- regulatory proteins and the convergence as well as integration of regulatory networks. The organization and localization of regulatory complexes within the nucleus can provide signatures that are linked to regulatory activity. Retention of transcription factors at gene loci in mitotic chromosomes contributes to epigenetic control of cell fate and lineage commitment, as well as to persistence of transformed and tumor phenotypes. Mechanistic understanding of the architectural assembly of regulatory machinery can serve as a basis for treating cancer with high specificity and minimal off-target effects.</p>
dc.identifier.submissionpathstein/238
dc.contributor.departmentDepartment of Cell Biology
dc.source.pages149-55


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