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dc.contributor.authorLian, Jane B.
dc.contributor.authorStein, Gary S.
dc.contributor.authorVan Wijnen, Andre J.
dc.contributor.authorStein, Janet L.
dc.contributor.authorHassan, Mohammad Q.
dc.contributor.authorGaur, Tripti
dc.contributor.authorZhang, Ying
dc.date2022-08-11T08:10:57.000
dc.date.accessioned2022-08-23T17:26:08Z
dc.date.available2022-08-23T17:26:08Z
dc.date.issued2012-01-31
dc.date.submitted2012-04-24
dc.identifier.citationNat Rev Endocrinol. 2012 Jan 31;8(4):212-27. doi: 10.1038/nrendo.2011.234. <a href="http://dx.doi.org/10.1038/nrendo.2011.234">Link to article on publisher's site</a>
dc.identifier.issn1759-5029 (Linking)
dc.identifier.doi10.1038/nrendo.2011.234
dc.identifier.pmid22290358
dc.identifier.urihttp://hdl.handle.net/20.500.14038/49572
dc.description.abstractMicroRNAs (miRNAs) repress cellular protein levels to provide a sophisticated parameter of gene regulation that coordinates a broad spectrum of biological processes. Bone organogenesis is a complex process involving the differentiation and crosstalk of multiple cell types for formation and remodeling of the skeleton. Inhibition of mRNA translation by miRNAs has emerged as an important regulator of developmental osteogenic signaling pathways, osteoblast growth and differentiation, osteoclast-mediated bone resorption activity and bone homeostasis in the adult skeleton. miRNAs control multiple layers of gene regulation for bone development and postnatal functions, from the initial response of stem/progenitor cells to the structural and metabolic activity of the mature tissue. This Review brings into focus an emerging concept of bone-regulating miRNAs, the evidence for which has been gathered largely from in vivo mouse models and in vitro studies in human and mouse skeletal cell populations. Characterization of miRNAs that operate through tissue-specific transcription factors in osteoblast and osteoclast lineage cells, as well as intricate feedforward and reverse loops, has provided novel insights into the supervision of signaling pathways and regulatory networks controlling normal bone formation and turnover. The current knowledge of miRNAs characteristic of human pathologic disorders of the skeleton is presented with a future goal towards translational studies.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=22290358&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1038/nrendo.2011.234
dc.subjectMicroRNAs
dc.subjectBone Development
dc.subjectBone and Bones
dc.subjectCell Biology
dc.titleMicroRNA control of bone formation and homeostasis
dc.typeJournal Article
dc.source.journaltitleNature reviews. Endocrinology
dc.source.volume8
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/stein/243
dc.identifier.contextkey2793373
html.description.abstract<p>MicroRNAs (miRNAs) repress cellular protein levels to provide a sophisticated parameter of gene regulation that coordinates a broad spectrum of biological processes. Bone organogenesis is a complex process involving the differentiation and crosstalk of multiple cell types for formation and remodeling of the skeleton. Inhibition of mRNA translation by miRNAs has emerged as an important regulator of developmental osteogenic signaling pathways, osteoblast growth and differentiation, osteoclast-mediated bone resorption activity and bone homeostasis in the adult skeleton. miRNAs control multiple layers of gene regulation for bone development and postnatal functions, from the initial response of stem/progenitor cells to the structural and metabolic activity of the mature tissue. This Review brings into focus an emerging concept of bone-regulating miRNAs, the evidence for which has been gathered largely from in vivo mouse models and in vitro studies in human and mouse skeletal cell populations. Characterization of miRNAs that operate through tissue-specific transcription factors in osteoblast and osteoclast lineage cells, as well as intricate feedforward and reverse loops, has provided novel insights into the supervision of signaling pathways and regulatory networks controlling normal bone formation and turnover. The current knowledge of miRNAs characteristic of human pathologic disorders of the skeleton is presented with a future goal towards translational studies.</p>
dc.identifier.submissionpathstein/243
dc.contributor.departmentDepartment of Cell Biology
dc.source.pages212-27


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