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dc.contributor.authorLiu, Lijun
dc.contributor.authorXie, Ronglin
dc.contributor.authorHussain, Sadiq
dc.contributor.authorLian, Jane B.
dc.contributor.authorRivera-Perez, Jaime A.
dc.contributor.authorJones, Stephen N.
dc.contributor.authorStein, Janet L.
dc.contributor.authorStein, Gary S.
dc.contributor.authorVan Wijnen, Andre J.
dc.date2022-08-11T08:10:57.000
dc.date.accessioned2022-08-23T17:26:11Z
dc.date.available2022-08-23T17:26:11Z
dc.date.issued2011-09-01
dc.date.submitted2012-04-24
dc.identifier.citationGene. 2011 Sep 1;483(1-2):1-10. Epub 2011 May 13. <a href="http://dx.doi.org/10.1016/j.gene.2011.05.002">Link to article on publisher's site</a>
dc.identifier.issn0378-1119 (Linking)
dc.identifier.doi10.1016/j.gene.2011.05.002
dc.identifier.pmid21605641
dc.identifier.urihttp://hdl.handle.net/20.500.14038/49583
dc.description.abstractTranscription factor Histone Nuclear Factor P (HiNF-P; gene symbol Hinfp) mediates cell cycle control of histone H4 gene expression to support the packaging of newly replicated DNA as chromatin. The HiNF-P/p220(NPAT) complex controls multiple H4 genes in established human cell lines and is critical for cell proliferation. The mouse Hinfp(LacZ) null allele causes early embryonic lethality due to a blastocyst defect. However, neither Hinfp function nor its temporal expression relative to histone H4 genes during fetal development has been explored. Here, we establish that expression of Hinfp is biologically coupled with expression of twelve functional mouse H4 genes during pre- and post-natal tissue-development. Both Hinfp and H4 genes are robustly expressed at multiple embryonic (E) days (from E5.5 to E15.5), coincident with ubiquitous LacZ staining driven by the Hinfp promoter. Five highly expressed mouse H4 genes (Hist1h4d, Histh4f, Hist1h4m and Hist2h4) account for >90% of total histone H4 mRNA throughout development. Post-natal expression of H4 genes in mice is most evident in lung, spleen, thymus and intestine, and with few exceptions (e.g., adult liver) correlates with Hinfp gene expression. Histone H4 gene expression decreases butHinfp levels remain constitutive upon cell growth inhibition in culture. The in vivo co-expression of Hinfp and histone H4 genes is consistent with the biological function of Hinfp as a principal transcriptional regulator of histone H4 gene expression during mouse development.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=21605641&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.gene.2011.05.002
dc.subjectAnimals
dc.subjectBlastocyst
dc.subjectCell Cycle
dc.subjectCells, Cultured
dc.subjectEmbryo, Mammalian
dc.subjectGene Expression
dc.subject*Gene Expression Regulation, Developmental
dc.subjectHistones
dc.subjectMice
dc.subjectMice, Inbred C57BL
dc.subjectRepressor Proteins
dc.subjectTissue Distribution
dc.subjectCell Biology
dc.titleFunctional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development
dc.typeArticle
dc.source.journaltitleGene
dc.source.volume483
dc.source.issue1-2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/stein/253
dc.identifier.contextkey2793383
html.description.abstract<p>Transcription factor Histone Nuclear Factor P (HiNF-P; gene symbol Hinfp) mediates cell cycle control of histone H4 gene expression to support the packaging of newly replicated DNA as chromatin. The HiNF-P/p220(NPAT) complex controls multiple H4 genes in established human cell lines and is critical for cell proliferation. The mouse Hinfp(LacZ) null allele causes early embryonic lethality due to a blastocyst defect. However, neither Hinfp function nor its temporal expression relative to histone H4 genes during fetal development has been explored. Here, we establish that expression of Hinfp is biologically coupled with expression of twelve functional mouse H4 genes during pre- and post-natal tissue-development. Both Hinfp and H4 genes are robustly expressed at multiple embryonic (E) days (from E5.5 to E15.5), coincident with ubiquitous LacZ staining driven by the Hinfp promoter. Five highly expressed mouse H4 genes (Hist1h4d, Histh4f, Hist1h4m and Hist2h4) account for >90% of total histone H4 mRNA throughout development. Post-natal expression of H4 genes in mice is most evident in lung, spleen, thymus and intestine, and with few exceptions (e.g., adult liver) correlates with Hinfp gene expression. Histone H4 gene expression decreases butHinfp levels remain constitutive upon cell growth inhibition in culture. The in vivo co-expression of Hinfp and histone H4 genes is consistent with the biological function of Hinfp as a principal transcriptional regulator of histone H4 gene expression during mouse development.</p>
dc.identifier.submissionpathstein/253
dc.contributor.departmentDepartment of Cell Biology
dc.source.pages1-10


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