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    Ajulemic acid, a nonpsychoactive cannabinoid acid, induces apoptosis in human T lymphocytes

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    Authors
    Bidinger, Bonnie
    Torres, Roxabella
    Rossetti, Ronald G.
    Brown, Lisa
    Beltre, Rosa
    Burstein, Sumner H.
    Lian, Jane B.
    Stein, Gary S.
    Zurier, Robert B.
    UMass Chan Affiliations
    Department of Medicine
    Department of Biochemistry and Molecular Pharmacology
    Department of Cell Biology
    Document Type
    Journal Article
    Publication Date
    2003-08-19
    Keywords
    Annexin A5
    Antirheumatic Agents
    Apoptosis
    Caspase 3
    Caspases
    Cell Division
    Cells, Cultured
    DNA Fragmentation
    Dose-Response Relationship, Drug
    Fluorescein-5-isothiocyanate
    Humans
    Microscopy, Fluorescence
    Molecular Structure
    T-Lymphocytes
    Tetrahydrocannabinol
    Cell Biology
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    Link to Full Text
    http://dx.doi.org/10.1016/S1521-6616(03)00064-0
    Abstract
    Oral administration of ajulemic acid (AjA), a synthetic nonpsychoactive cannabinoid acid, prevents joint cartilage and bone damage in an experimental model of arthritis in rats. Joint tissue injury in patients with rheumatoid arthritis (RA) is due in part to activation of T lymphocytes in the synovium, and T lymphocytes in synovium of RA patients are resistant to apoptosis. Thus, a potential mechanism whereby AjA prevents joint tissue injury in the animal model might be enhanced apoptosis of T lymphocytes. Apoptosis of human T cells in vitro was assessed by Annexin V expression, caspase-3 activity, DNA fragmentation, and microscopy. AjA induced apoptosis of T cells in a dose- and time-dependent manner. Apoptosis preceded loss of cell viability by trypan blue dye exclusion, confirming that cell loss was due to programmed cell death rather than necrosis. A nontoxic compound such as AjA may be a useful therapeutic agent for patients with diseases such as RA which are characterized by T-cell-driven chronic inflammation and tissue injury.
    Source
    Clin Immunol. 2003 Aug;108(2):95-102.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/49633
    PubMed ID
    12921755
    Related Resources
    Link to Article in PubMed
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    UMass Chan Faculty and Researcher Publications

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