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dc.contributor.authorSigler, Paul B.
dc.contributor.authorStein, Gary S.
dc.contributor.authorBoskey, Adele L.
dc.contributor.authorJones, Noel D.
dc.contributor.authorKuriyan, John
dc.contributor.authorMiller, William M.
dc.contributor.authorShuler, Michael L.
dc.contributor.authorWang, Bi-Cheng
dc.date2022-08-11T08:10:57.000
dc.date.accessioned2022-08-23T17:26:27Z
dc.date.available2022-08-23T17:26:27Z
dc.date.issued2000-09-21
dc.date.submitted2011-01-11
dc.identifier.citationJ Cell Biochem. 2000 Sep 14;79(4):662-71.
dc.identifier.issn0730-2312 (Linking)
dc.identifier.pmid10996856
dc.identifier.urihttp://hdl.handle.net/20.500.14038/49639
dc.description.abstractThe recent National Research Council report, Future Biotechnology Research on the International Space Station, evaluates NASA's plans for research in cell science and protein crystal growth to be conducted on the International Space Station. This report concludes that the NASA biotechnology programs have the potential to significantly impact relevant scientific fields and to increase understanding and insight into fundamental biological issues. In order to realize the potential impacts, NASA must focus its research programs by selecting specific questions related to gravitational forces' role in cell behavior and by using the microgravity environment as a tool to determine the structure of macromolecules with important biological implications. Given the time and volume constraints associated with space-based experiments, instrumentation to be used on the space station must be designed to maximize the productivity of researchers, and NASA's recruitment of investigators and support for space station experiments should aim to encourage and facilitate cutting-edge research.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=10996856&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1002/1097-4644(20001215)79:4<662::AID-JCB140>3.0.CO;2-4
dc.subjectBiotechnology
dc.subject*Cell Culture Techniques
dc.subjectCrystallization
dc.subjectProteins
dc.subjectResearch Design
dc.subject*Space Flight
dc.subjectUnited States
dc.subjectUnited States National Aeronautics and Space Administration
dc.subject*Weightlessness
dc.subjectCell Biology
dc.titleCell science and protein crystal growth research for the International Space Station
dc.typeJournal Article
dc.source.journaltitleJournal of cellular biochemistry
dc.source.volume79
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/stein/66
dc.identifier.contextkey1724106
html.description.abstract<p>The recent National Research Council report, Future Biotechnology Research on the International Space Station, evaluates NASA's plans for research in cell science and protein crystal growth to be conducted on the International Space Station. This report concludes that the NASA biotechnology programs have the potential to significantly impact relevant scientific fields and to increase understanding and insight into fundamental biological issues. In order to realize the potential impacts, NASA must focus its research programs by selecting specific questions related to gravitational forces' role in cell behavior and by using the microgravity environment as a tool to determine the structure of macromolecules with important biological implications. Given the time and volume constraints associated with space-based experiments, instrumentation to be used on the space station must be designed to maximize the productivity of researchers, and NASA's recruitment of investigators and support for space station experiments should aim to encourage and facilitate cutting-edge research.</p>
dc.identifier.submissionpathstein/66
dc.contributor.departmentDepartment of Cell Biology
dc.source.pages662-71


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