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dc.contributor.authorPrushik, Scott G.
dc.contributor.authorFarber, Alik
dc.contributor.authorGona, Philimon
dc.contributor.authorShrader, Peter
dc.contributor.authorPencina, Michael J.
dc.contributor.authorD'Agostino, Ralph B.
dc.contributor.authorMurabito, Joanne M.
dc.date2022-08-11T08:10:58.000
dc.date.accessioned2022-08-23T17:26:42Z
dc.date.available2022-08-23T17:26:42Z
dc.date.issued2012-03-01
dc.date.submitted2012-10-29
dc.identifier.citation<p>Am J Cardiol. 2012 Mar 1;109(5):736-41. Epub 2011 Dec 10. DOI 10.1016/j.amjcard.2011.10.032. <a href="http://dx.doi.org/10.1016/j.amjcard.2011.10.032">Link to article on publisher's website</a></p>
dc.identifier.issn1879-1913
dc.identifier.doi10.1016/j.amjcard.2011.10.032
dc.identifier.pmid22154319
dc.identifier.urihttp://hdl.handle.net/20.500.14038/49697
dc.description.abstractLittle is known about the familial aggregation of intermittent claudication (IC). Our objective was to examine whether parental IC increased the risk of IC in adult offspring, independent of the established cardiovascular risk factors. We evaluated the Offspring Cohort Participants of the Framingham Heart Study who were ≥30 years old, cardiovascular disease free, and had both parents enrolled in the Framingham Heart Study (n = 2,970 unique participants, 53% women). Pooled proportional hazards regression analysis was used to examine whether the 12-year risk of incident IC in offspring participants was associated with parental IC, adjusting for age, gender, diabetes, smoking, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, and antihypertensive and lipid treatment. Of the 909 person-examinations in the parental IC history group and 5,397 person-examinations in the no-parental IC history group, there were 101 incident IC events (29 with parental IC history and 72 without a parental IC history) during follow-up. The age- and gender-adjusted 12-year cumulative incidence rate per 1,000 person-years was 5.08 (95% confidence interval [CI] 2.74 to 7.33) and 2.34 (95% CI 1.46 to 3.19) in participants with and without a parental IC history. A parental history of IC significantly increased the risk of incident IC in the offspring (multivariable adjusted hazard ratio 1.81, 95% CI 1.14 to 2.88). The hazard ratio was unchanged, with an adjustment for the occurrence of cardiovascular disease (hazard ratio 1.83, 95% CI 1.15 to 2.91). In conclusion, IC in parents increases the risk of IC in adult offspring, independent of the established risk factors. These data suggest a genetic component of peripheral artery disease and support future research into genetic causes.
dc.language.isoen_US
dc.publisherExcerpta Medica
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22154319&dopt=Abstract">Link to article in PubMed</a></p>
dc.relation.urlhttp://dx.doi.org/10.1016/j.amjcard.2011.10.032
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectGenetic Predisposition to Disease
dc.subjectHumans
dc.subjectIncidence
dc.subjectIntermittent Claudication
dc.subjectMale
dc.subjectMassachusetts
dc.subjectMiddle Aged
dc.subjectParents
dc.subjectPrognosis
dc.subjectProspective Studies
dc.subjectTime Factors
dc.subjectYoung Adult
dc.subjectCardiovascular Diseases
dc.subjectSurgery
dc.titleParental intermittent claudication as risk factor for claudication in adults
dc.typeJournal Article
dc.source.journaltitleThe American journal of cardiology
dc.source.volume109
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/surgery_pp/124
dc.identifier.contextkey3431024
html.description.abstract<p>Little is known about the familial aggregation of intermittent claudication (IC). Our objective was to examine whether parental IC increased the risk of IC in adult offspring, independent of the established cardiovascular risk factors. We evaluated the Offspring Cohort Participants of the Framingham Heart Study who were ≥30 years old, cardiovascular disease free, and had both parents enrolled in the Framingham Heart Study (n = 2,970 unique participants, 53% women). Pooled proportional hazards regression analysis was used to examine whether the 12-year risk of incident IC in offspring participants was associated with parental IC, adjusting for age, gender, diabetes, smoking, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, and antihypertensive and lipid treatment. Of the 909 person-examinations in the parental IC history group and 5,397 person-examinations in the no-parental IC history group, there were 101 incident IC events (29 with parental IC history and 72 without a parental IC history) during follow-up. The age- and gender-adjusted 12-year cumulative incidence rate per 1,000 person-years was 5.08 (95% confidence interval [CI] 2.74 to 7.33) and 2.34 (95% CI 1.46 to 3.19) in participants with and without a parental IC history. A parental history of IC significantly increased the risk of incident IC in the offspring (multivariable adjusted hazard ratio 1.81, 95% CI 1.14 to 2.88). The hazard ratio was unchanged, with an adjustment for the occurrence of cardiovascular disease (hazard ratio 1.83, 95% CI 1.15 to 2.91). In conclusion, IC in parents increases the risk of IC in adult offspring, independent of the established risk factors. These data suggest a genetic component of peripheral artery disease and support future research into genetic causes.</p>
dc.identifier.submissionpathsurgery_pp/124
dc.contributor.departmentDepartment of Vascular Surgery
dc.source.pages736-41


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