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dc.contributor.authorMahboub, Paria
dc.contributor.authorBozorgzadeh, Adel
dc.contributor.authorMartins, Paulo N.A.
dc.date2022-08-11T08:10:58.000
dc.date.accessioned2022-08-23T17:26:53Z
dc.date.available2022-08-23T17:26:53Z
dc.date.issued2016-06-24
dc.date.submitted2019-05-01
dc.identifier.citation<p>World J Transplant. 2016 Jun 24;6(2):314-20. doi: 10.5500/wjt.v6.i2.314. <a href="https://doi.org/10.5500/wjt.v6.i2.314">Link to article on publisher's site</a></p>
dc.identifier.issn2220-3230 (Linking)
dc.identifier.doi10.5500/wjt.v6.i2.314
dc.identifier.pmid27358776
dc.identifier.urihttp://hdl.handle.net/20.500.14038/49738
dc.description.abstractThere is a growing discrepancy between the supply and demand of livers for transplantation resulting in high mortality rates on the waiting list. One of the options to decrease the mortality on the waiting list is to optimize organs with inferior quality that otherwise would be discarded. Livers from donation after cardiac death (DCD) donors are frequently discarded because they are exposed to additional warm ischemia time, and this might lead to primary-non-function, delayed graft function, or severe biliary complications. In order to maximize the usage of DCD livers several new preservation approaches have been proposed. Here, we will review 3 innovative organ preservation methods: (1) different ex vivo perfusion techniques; (2) persufflation with oxygen; and (3) addition of thrombolytic therapy. Improvement of the quality of DCD liver grafts could increase the pool of liver graft's for transplantation, improve the outcomes, and decrease the mortality on the waiting list.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=27358776&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsThis article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectBiliary complications
dc.subjectDonation after cardiac death
dc.subjectOrgan preservation methods
dc.subjectAnalytical, Diagnostic and Therapeutic Techniques and Equipment
dc.subjectDigestive System
dc.subjectHepatology
dc.subjectSurgery
dc.titlePotential approaches to improve the outcomes of donation after cardiac death liver grafts
dc.typeJournal Article
dc.source.journaltitleWorld journal of transplantation
dc.source.volume6
dc.source.issue2
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1162&amp;context=surgery_pp&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/surgery_pp/163
dc.identifier.contextkey14402105
refterms.dateFOA2022-08-23T17:26:54Z
html.description.abstract<p>There is a growing discrepancy between the supply and demand of livers for transplantation resulting in high mortality rates on the waiting list. One of the options to decrease the mortality on the waiting list is to optimize organs with inferior quality that otherwise would be discarded. Livers from donation after cardiac death (DCD) donors are frequently discarded because they are exposed to additional warm ischemia time, and this might lead to primary-non-function, delayed graft function, or severe biliary complications. In order to maximize the usage of DCD livers several new preservation approaches have been proposed. Here, we will review 3 innovative organ preservation methods: (1) different ex vivo perfusion techniques; (2) persufflation with oxygen; and (3) addition of thrombolytic therapy. Improvement of the quality of DCD liver grafts could increase the pool of liver graft's for transplantation, improve the outcomes, and decrease the mortality on the waiting list.</p>
dc.identifier.submissionpathsurgery_pp/163
dc.contributor.departmentDepartment of Surgery, Division of Transplantation
dc.source.pages314-20


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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Except where otherwise noted, this item's license is described as This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/