Normothermic machine preservation as an approach to decrease biliary complications of DCD liver grafts
Authors
Martins, Paulo N.A.UMass Chan Affiliations
Department of Surgery, Transplant and Hepatobiliary Surgery Division, UMass Memorial Medical CenterDocument Type
Letter to the EditorPublication Date
2013-12-01
Metadata
Show full item recordAbstract
Because of frequent biliary complications, it is crucial to develop new strategies to improve the quality of donors after cardiac death (DCD) liver grafts. I read with interest the article by Boehnert et al . The rate and severity of biliary epithelium damage they have reported after 60 min of warm ischemia and an additional 4–12 h of cold is extremely low compared to what has been published before and overestimates in large scale the potential benefit that machine perfusion can provide. They showed that despite this massive ischemic insult, four out of five DCD grafts on machine preservation had no detectable injury, with intact mucosa lining of the bile duct at the end of blood reperfusion, while the control group had 100% necrosis.Source
Am J Transplant. 2013 Dec;13(12):3287-8. doi: 10.1111/ajt.12497. Epub 2013 Oct 21. Link to article on publisher's site
DOI
10.1111/ajt.12497Permanent Link to this Item
http://hdl.handle.net/20.500.14038/49746PubMed ID
24148669Related Resources
ae974a485f413a2113503eed53cd6c53
10.1111/ajt.12497