Liver Transplantation for Unresectable Colorectal Cancer Liver Metastases: A Paradigm Change?
UMass Chan Affiliations
Department of Surgery, Division of Transplantation, UMass Memorial Medical CenterDocument Type
Letter to the EditorPublication Date
2015-07-01
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Show full item recordAbstract
Historically, colorectal cancer liver metastases have been considered a terminal disease. In the last 20 years, despite dramatic improvements in treatment, especially neoadjuvant therapy and liver resection, the prognosis for patients with nonresectable colorectal carcinoma (NRCRC) liver metastases remains dismal. Colorectal cancer metastases are considered an absolute contraindication for liver transplant because historically results were very poor. Hagness et al. challenged the status quo by revisiting the idea of liver transplantation for NRCRC liver metastases. The estimated overall 5-year survival rate after transplant in their study was 60% compared with only 18% in previous reports. This is a major achievement, considering that chemotherapy alone typically results in a 5-year survival rate of only 5% to 10%.Source
Ann Surg. 2015 Jul;262(1):e12. doi: 10.1097/SLA.0000000000000483. Link to article on publisher's site
DOI
10.1097/SLA.0000000000000483Permanent Link to this Item
http://hdl.handle.net/20.500.14038/49748PubMed ID
24424153Related Resources
ae974a485f413a2113503eed53cd6c53
10.1097/SLA.0000000000000483