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dc.contributor.authorTseng, Jennifer F.
dc.contributor.authorWarshaw, Andrew L.
dc.contributor.authorSahani, Dushant V.
dc.contributor.authorLauwers, Gregory Y.
dc.contributor.authorRattner, David W.
dc.contributor.authorFernandez-del Castillo, Carlos
dc.date2022-08-11T08:10:58.000
dc.date.accessioned2022-08-23T17:27:03Z
dc.date.available2022-08-23T17:27:03Z
dc.date.issued2005-09-02
dc.date.submitted2011-06-21
dc.identifier.citationAnn Surg. 2005 Sep;242(3):413-9; discussion 419-21. <a href="http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000658-200509000-00012&LSLINK=80&D=ovft">Link to article on publisher's website</a>
dc.identifier.issn0003-4932 (Linking)
dc.identifier.pmid16135927
dc.identifier.urihttp://hdl.handle.net/20.500.14038/49775
dc.description.abstractOBJECTIVE: To define the natural history and optimal management of serous cystadenoma of the pancreas. SUMMARY BACKGROUND DATA: Serous cystadenoma of the pancreas is the most common benign pancreatic neoplasm. Diagnostic criteria, potential for growth or malignancy, and outcomes are not well defined. As a result, management for patients with serous cystadenomas varies widely in current practice. METHODS: A total of 106 patients presenting with serous cystadenoma of the pancreas from 1976-2004 were identified. Hospital records were evaluated for patient and tumor characteristics, diagnostic workup, treatment, and outcome. Twenty-four patients with serial radiographic imaging were identified, and tumor growth curves calculated. RESULTS: Mean age at presentation was 61.5 years and 75% of patients were female. The most common symptoms were abdominal pain (25%), fullness/mass (10%), and jaundice (7%); 47% were asymptomatic. Mean tumor diameter was 4.9 +/- 3.1 cm, which did not vary by location. Tumors <4 cm were less likely to be symptomatic than were tumors> or =4 cm (22% vs. 72%, P < 0.001). The median growth rate in the patients who had serial radiography was 0.60 cm/y. For tumors <4 cm at presentation (n = 15), the rate was 0.12 cm/y, whereas for tumors > or =4 cm (n = 9), the rate was 1.98 cm/y (P = 0.0002). Overall, 86 patients underwent surgery, with one perioperative death. CONCLUSIONS: Large (>4 cm) serous cystadenomas are more likely to be symptomatic. Although the median growth rate for this neoplasm is only 0.6 cm/y, it is significantly greater in large tumors. Whereas expectant management is reasonable in small asymptomatic tumors, we recommend resection for large serous cystadenomas regardless of the presence or absence of symptoms.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=16135927&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1357749/pdf/20050900s00012p413.pdf
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectCystadenoma, Serous
dc.subjectDisease Progression
dc.subjectFemale
dc.subjectHealth Planning Guidelines
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPancreatic Neoplasms
dc.subjectTomography, X-Ray Computed
dc.subjectSurgery
dc.titleSerous cystadenoma of the pancreas: tumor growth rates and recommendations for treatment
dc.typeJournal Article
dc.source.journaltitleAnnals of surgery
dc.source.volume242
dc.source.issue3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/surgery_pp/50
dc.identifier.contextkey2069146
html.description.abstract<p>OBJECTIVE: To define the natural history and optimal management of serous cystadenoma of the pancreas. SUMMARY BACKGROUND DATA: Serous cystadenoma of the pancreas is the most common benign pancreatic neoplasm. Diagnostic criteria, potential for growth or malignancy, and outcomes are not well defined. As a result, management for patients with serous cystadenomas varies widely in current practice. METHODS: A total of 106 patients presenting with serous cystadenoma of the pancreas from 1976-2004 were identified. Hospital records were evaluated for patient and tumor characteristics, diagnostic workup, treatment, and outcome. Twenty-four patients with serial radiographic imaging were identified, and tumor growth curves calculated. RESULTS: Mean age at presentation was 61.5 years and 75% of patients were female. The most common symptoms were abdominal pain (25%), fullness/mass (10%), and jaundice (7%); 47% were asymptomatic. Mean tumor diameter was 4.9 +/- 3.1 cm, which did not vary by location. Tumors <4 cm were less likely to be symptomatic than were tumors> or =4 cm (22% vs. 72%, P < 0.001). The median growth rate in the patients who had serial radiography was 0.60 cm/y. For tumors <4 cm at presentation (n = 15), the rate was 0.12 cm/y, whereas for tumors > or =4 cm (n = 9), the rate was 1.98 cm/y (P = 0.0002). Overall, 86 patients underwent surgery, with one perioperative death. CONCLUSIONS: Large (>4 cm) serous cystadenomas are more likely to be symptomatic. Although the median growth rate for this neoplasm is only 0.6 cm/y, it is significantly greater in large tumors. Whereas expectant management is reasonable in small asymptomatic tumors, we recommend resection for large serous cystadenomas regardless of the presence or absence of symptoms.</p>
dc.identifier.submissionpathsurgery_pp/50
dc.contributor.departmentDepartment of Surgery
dc.source.pages413-9; discussion 419-21


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