In-hospital mortality after pancreatic resection for chronic pancreatitis: population-based estimates from the nationwide inpatient sample
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Authors
Hill, Joshua S.McPhee, James T.
Whalen, Giles F.
Sullivan, Mary E.
Warshaw, Andrew L.
Tseng, Jennifer F.
UMass Chan Affiliations
Department of SurgeryDocument Type
Journal ArticlePublication Date
2009-10-06Keywords
AgedAged, 80 and over
Chi-Square Distribution
Chronic Disease
Comorbidity
Female
Hospital Mortality
Humans
Inpatients
Male
Middle Aged
Multivariate Analysis
Pancreatectomy
Pancreatic Neoplasms
Pancreatitis
United States
Surgery
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Show full item recordAbstract
BACKGROUND: Pancreatic resection can be performed to ameliorate the sequelae of chronic pancreatitis in selected patients. The perceived risk of pancreatectomy may limit its use. Using a national database, this study compared mortality after pancreatic resections for chronic pancreatitis with those performed for neoplasm. STUDY DESIGN: Patient discharges with chronic pancreatitis or pancreatic neoplasm were queried from the Nationwide Inpatient Sample, 1998 to 2006. To account for the Nationwide Inpatient Sample weighting schema, design-adjusted analyses were used. RESULTS: There were 11,048 pancreatic resections. Malignant neoplasms represented 64.2% of the sample; benign neoplasms and pancreatitis comprised 17.1% and 18.7%, respectively. In-hospital mortality rates were 2.2% and 1.7% for the pancreatitis and benign tumor cohorts, respectively, compared with 5.9% for the malignancy cohort (overall p < 0.01). A multivariable logistic regression examined differences in mortality among diagnoses while adjusting for patient and hospital characteristics; covariates included patient gender, race, age, comorbidities, type of pancreatectomy, payor, hospital teaching status, hospital size, and hospital volume. After adjustment, patients undergoing resection for pancreatitis were at a significantly lower risk of in-hospital mortality when compared with those with malignant neoplasm (odds ratio, 0.43; 95% CI, 0.28 to 0.67). CONCLUSIONS: Pancreatectomies for chronic pancreatitis have lower in-hospital mortality than those performed for malignancy and similar rates as resection for benign tumors. Pancreatic resection, which can improve quality of life in chronic pancreatitis patients, can be performed with moderate mortality rates and should be considered in appropriate patients.Source
J Am Coll Surg. 2009 Oct;209(4):468-76. Epub 2009 Aug 20. Link to article on publisher's siteDOI
10.1016/j.jamcollsurg.2009.05.030Permanent Link to this Item
http://hdl.handle.net/20.500.14038/49784PubMed ID
19801320Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.jamcollsurg.2009.05.030