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dc.contributor.authorGlazer, Evan S.
dc.contributor.authorTseng, Jennifer F.
dc.contributor.authorAl-Refaie, Waddah B.
dc.contributor.authorSolorzano, Carmen C.
dc.contributor.authorLiu, Ping
dc.contributor.authorWillborn, Katherine A.
dc.contributor.authorAbdalla, Eddie K.
dc.contributor.authorVauthey, Jean-Nicolas
dc.contributor.authorCurley, Steven A.
dc.date2022-08-11T08:10:59.000
dc.date.accessioned2022-08-23T17:27:10Z
dc.date.available2022-08-23T17:27:10Z
dc.date.issued2010-07-29
dc.date.submitted2011-06-21
dc.identifier.citationHPB (Oxford). 2010 Aug;12(6):427-33. <a href="http://dx.doi.org/10.1111/j.1477-2574.2010.00198.x">Link to article on publisher's site</a>
dc.identifier.issn1365-182X (Linking)
dc.identifier.doi10.1111/j.1477-2574.2010.00198.x
dc.identifier.pmid20662794
dc.identifier.urihttp://hdl.handle.net/20.500.14038/49800
dc.description.abstractBACKGROUND: Surgical cytoreduction and endocrine blockade are important options for care for neuroendocrine liver metastases. We investigated the long-term survival of patients surgically treated for hepatic neuroendocrine metastases. METHODS: Patients (n= 172) undergoing operations for neuroendocrine liver metastases from any primary were identified from a prospective liver database. Recorded data and medical record review were used to analyse the type of procedure, length of hospital stay, peri-operative morbidity, tumour recurrence, progression,and survival. RESULTS: The median age was 56.8 years (range 11.5-80.7 years). 48.3% of patients were female. Median overall survival was 9.6 years (range 89 days to 22 years). On multivariate analysis, lung/thymic primaries were associated with worse survival [hazard ratio (HR): 15.6, confidence interval (CI): 4.3-56.8, P= 0.002]. Severe post-operative complications were also associated with worse long-term survival (P < 0.001). A positive resection margin status (R1) was not associated with a worse overall survival probability (P approximately 0.8). DISCUSSION: Early and aggressive surgical management of hepatic metastases from neuroendocrine tumours is associated with significant long-term survival rates. Radiofrequency ablation is a reasonable option if a lesion is unresectable. R1 resections, unlike many other cancers, are not associated with a worse overall survival.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=20662794&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1111/j.1477-2574.2010.00198.x
dc.subjectDigestive System Surgical Procedures
dc.subjectLiver Neoplasms
dc.subjectNeuroendocrine Tumors
dc.subjectSurvivors
dc.subjectSurgery
dc.titleLong-term survival after surgical management of neuroendocrine hepatic metastases
dc.typeJournal Article
dc.source.journaltitleHPB : the official journal of the International Hepato Pancreato Biliary Association
dc.source.volume12
dc.source.issue6
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/surgery_pp/73
dc.identifier.contextkey2069170
html.description.abstract<p>BACKGROUND: Surgical cytoreduction and endocrine blockade are important options for care for neuroendocrine liver metastases. We investigated the long-term survival of patients surgically treated for hepatic neuroendocrine metastases.</p> <p>METHODS: Patients (n= 172) undergoing operations for neuroendocrine liver metastases from any primary were identified from a prospective liver database. Recorded data and medical record review were used to analyse the type of procedure, length of hospital stay, peri-operative morbidity, tumour recurrence, progression,and survival.</p> <p>RESULTS: The median age was 56.8 years (range 11.5-80.7 years). 48.3% of patients were female. Median overall survival was 9.6 years (range 89 days to 22 years). On multivariate analysis, lung/thymic primaries were associated with worse survival [hazard ratio (HR): 15.6, confidence interval (CI): 4.3-56.8, P= 0.002]. Severe post-operative complications were also associated with worse long-term survival (P < 0.001). A positive resection margin status (R1) was not associated with a worse overall survival probability (P approximately 0.8).</p> <p>DISCUSSION: Early and aggressive surgical management of hepatic metastases from neuroendocrine tumours is associated with significant long-term survival rates. Radiofrequency ablation is a reasonable option if a lesion is unresectable. R1 resections, unlike many other cancers, are not associated with a worse overall survival.</p>
dc.identifier.submissionpathsurgery_pp/73
dc.contributor.departmentDepartment of Surgery
dc.source.pages427-33


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