Long-term survival after surgical management of neuroendocrine hepatic metastases
dc.contributor.author | Glazer, Evan S. | |
dc.contributor.author | Tseng, Jennifer F. | |
dc.contributor.author | Al-Refaie, Waddah B. | |
dc.contributor.author | Solorzano, Carmen C. | |
dc.contributor.author | Liu, Ping | |
dc.contributor.author | Willborn, Katherine A. | |
dc.contributor.author | Abdalla, Eddie K. | |
dc.contributor.author | Vauthey, Jean-Nicolas | |
dc.contributor.author | Curley, Steven A. | |
dc.date | 2022-08-11T08:10:59.000 | |
dc.date.accessioned | 2022-08-23T17:27:10Z | |
dc.date.available | 2022-08-23T17:27:10Z | |
dc.date.issued | 2010-07-29 | |
dc.date.submitted | 2011-06-21 | |
dc.identifier.citation | HPB (Oxford). 2010 Aug;12(6):427-33. <a href="http://dx.doi.org/10.1111/j.1477-2574.2010.00198.x">Link to article on publisher's site</a> | |
dc.identifier.issn | 1365-182X (Linking) | |
dc.identifier.doi | 10.1111/j.1477-2574.2010.00198.x | |
dc.identifier.pmid | 20662794 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/49800 | |
dc.description.abstract | BACKGROUND: Surgical cytoreduction and endocrine blockade are important options for care for neuroendocrine liver metastases. We investigated the long-term survival of patients surgically treated for hepatic neuroendocrine metastases. METHODS: Patients (n= 172) undergoing operations for neuroendocrine liver metastases from any primary were identified from a prospective liver database. Recorded data and medical record review were used to analyse the type of procedure, length of hospital stay, peri-operative morbidity, tumour recurrence, progression,and survival. RESULTS: The median age was 56.8 years (range 11.5-80.7 years). 48.3% of patients were female. Median overall survival was 9.6 years (range 89 days to 22 years). On multivariate analysis, lung/thymic primaries were associated with worse survival [hazard ratio (HR): 15.6, confidence interval (CI): 4.3-56.8, P= 0.002]. Severe post-operative complications were also associated with worse long-term survival (P < 0.001). A positive resection margin status (R1) was not associated with a worse overall survival probability (P approximately 0.8). DISCUSSION: Early and aggressive surgical management of hepatic metastases from neuroendocrine tumours is associated with significant long-term survival rates. Radiofrequency ablation is a reasonable option if a lesion is unresectable. R1 resections, unlike many other cancers, are not associated with a worse overall survival. | |
dc.language.iso | en_US | |
dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=20662794&dopt=Abstract">Link to Article in PubMed</a> | |
dc.relation.url | http://dx.doi.org/10.1111/j.1477-2574.2010.00198.x | |
dc.subject | Digestive System Surgical Procedures | |
dc.subject | Liver Neoplasms | |
dc.subject | Neuroendocrine Tumors | |
dc.subject | Survivors | |
dc.subject | Surgery | |
dc.title | Long-term survival after surgical management of neuroendocrine hepatic metastases | |
dc.type | Journal Article | |
dc.source.journaltitle | HPB : the official journal of the International Hepato Pancreato Biliary Association | |
dc.source.volume | 12 | |
dc.source.issue | 6 | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/surgery_pp/73 | |
dc.identifier.contextkey | 2069170 | |
html.description.abstract | <p>BACKGROUND: Surgical cytoreduction and endocrine blockade are important options for care for neuroendocrine liver metastases. We investigated the long-term survival of patients surgically treated for hepatic neuroendocrine metastases.</p> <p>METHODS: Patients (n= 172) undergoing operations for neuroendocrine liver metastases from any primary were identified from a prospective liver database. Recorded data and medical record review were used to analyse the type of procedure, length of hospital stay, peri-operative morbidity, tumour recurrence, progression,and survival.</p> <p>RESULTS: The median age was 56.8 years (range 11.5-80.7 years). 48.3% of patients were female. Median overall survival was 9.6 years (range 89 days to 22 years). On multivariate analysis, lung/thymic primaries were associated with worse survival [hazard ratio (HR): 15.6, confidence interval (CI): 4.3-56.8, P= 0.002]. Severe post-operative complications were also associated with worse long-term survival (P < 0.001). A positive resection margin status (R1) was not associated with a worse overall survival probability (P approximately 0.8).</p> <p>DISCUSSION: Early and aggressive surgical management of hepatic metastases from neuroendocrine tumours is associated with significant long-term survival rates. Radiofrequency ablation is a reasonable option if a lesion is unresectable. R1 resections, unlike many other cancers, are not associated with a worse overall survival.</p> | |
dc.identifier.submissionpath | surgery_pp/73 | |
dc.contributor.department | Department of Surgery | |
dc.source.pages | 427-33 |