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    Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains

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    Authors
    Oudelaar, A. Marieke
    Davies, James O. J.
    Hanssen, Lars L. P.
    Telenius, Jelena M.
    Schwessinger, Ron
    Liu, Yu
    Brown, Jill M.
    Downes, Damien J.
    Chiariello, Andrea M.
    Bianco, Simona
    Nicodemi, Mario
    Buckle, Veronica J.
    Dekker, Job
    Higgs, Douglas R.
    Hughes, Jim R.
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    UMass Chan Affiliations
    Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology
    Document Type
    Journal Article
    Publication Date
    2018-12-01
    Keywords
    Amino Acids, Peptides, and Proteins
    Cells
    Computational Biology
    Genetic Phenomena
    Molecular Biology
    Structural Biology
    Systems Biology
    
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    Link to Full Text
    https://doi.org/10.1038/s41588-018-0253-2
    Abstract
    The promoters of mammalian genes are commonly regulated by multiple distal enhancers, which physically interact within discrete chromatin domains. How such domains form and how the regulatory elements within them interact in single cells is not understood. To address this we developed Tri-C, a new chromosome conformation capture (3C) approach, to characterize concurrent chromatin interactions at individual alleles. Analysis by Tri-C identifies heterogeneous patterns of single-allele interactions between CTCF boundary elements, indicating that the formation of chromatin domains likely results from a dynamic process. Within these domains, we observe specific higher-order structures that involve simultaneous interactions between multiple enhancers and promoters. Such regulatory hubs provide a structural basis for understanding how multiple cis-regulatory elements act together to establish robust regulation of gene expression.
    Source

    Nat Genet. 2018 Dec;50(12):1744-1751. doi: 10.1038/s41588-018-0253-2. Epub 2018 Oct 29. Link to article on publisher's site

    DOI
    10.1038/s41588-018-0253-2
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/49881
    PubMed ID
    30374068
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1038/s41588-018-0253-2
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