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UMass Chan Affiliations
Department of Biochemistry and Molecular PharmacologyProgram in Systems Biology
Document Type
Journal ArticlePublication Date
2013-03-07Keywords
GenomeChromosome Structures
Protein Conformation
Protein Folding
Gene Expression Regulation
Genetics and Genomics
Molecular Biology
Systems Biology
Metadata
Show full item recordAbstract
Mammalian genomes encode genetic information in their linear sequence, but appropriate expression of their genes requires chromosomes to fold into complex three-dimensional structures. Transcriptional control involves the establishment of physical connections among genes and regulatory elements, both along and between chromosomes. Recent technological innovations in probing the folding of chromosomes are providing new insights into the spatial organization of genomes and its role in gene regulation. It is emerging that folding of large complex chromosomes involves a hierarchy of structures, from chromatin loops that connect genes and enhancers to larger chromosomal domains and nuclear compartments. The larger these structures are along this hierarchy, the more stable they are within cells, while becoming more stochastic between cells. Here, we review the experimental and theoretical data on this hierarchy of structures and propose a key role for the recently discovered topologically associating domains.Source
Mol Cell. 2013 Mar 7;49(5):773-82. doi: 10.1016/j.molcel.2013.02.011. Link to article on publisher's siteDOI
10.1016/j.molcel.2013.02.011Permanent Link to this Item
http://hdl.handle.net/20.500.14038/49902PubMed ID
23473598Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.molcel.2013.02.011