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dc.contributor.authorGibcus, Johan H.
dc.contributor.authorDekker, Job
dc.date2022-08-11T08:10:59.000
dc.date.accessioned2022-08-23T17:27:37Z
dc.date.available2022-08-23T17:27:37Z
dc.date.issued2013-03-07
dc.date.submitted2013-04-08
dc.identifier.citationMol Cell. 2013 Mar 7;49(5):773-82. doi: 10.1016/j.molcel.2013.02.011. <a href="http://dx.doi.org/10.1016/j.molcel.2013.02.011" target="_blank">Link to article on publisher's site</a></p>
dc.identifier.issn1097-2765 (Linking)
dc.identifier.doi10.1016/j.molcel.2013.02.011
dc.identifier.pmid23473598
dc.identifier.urihttp://hdl.handle.net/20.500.14038/49902
dc.description.abstractMammalian genomes encode genetic information in their linear sequence, but appropriate expression of their genes requires chromosomes to fold into complex three-dimensional structures. Transcriptional control involves the establishment of physical connections among genes and regulatory elements, both along and between chromosomes. Recent technological innovations in probing the folding of chromosomes are providing new insights into the spatial organization of genomes and its role in gene regulation. It is emerging that folding of large complex chromosomes involves a hierarchy of structures, from chromatin loops that connect genes and enhancers to larger chromosomal domains and nuclear compartments. The larger these structures are along this hierarchy, the more stable they are within cells, while becoming more stochastic between cells. Here, we review the experimental and theoretical data on this hierarchy of structures and propose a key role for the recently discovered topologically associating domains.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23473598&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.molcel.2013.02.011
dc.subjectGenome
dc.subjectChromosome Structures
dc.subjectProtein Conformation
dc.subjectProtein Folding
dc.subjectGene Expression Regulation
dc.subjectGenetics and Genomics
dc.subjectMolecular Biology
dc.subjectSystems Biology
dc.titleThe Hierarchy of the 3D Genome
dc.typeJournal Article
dc.source.journaltitleMolecular cell
dc.source.volume49
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/sysbio_pubs/20
dc.identifier.contextkey4007875
html.description.abstract<p>Mammalian genomes encode genetic information in their linear sequence, but appropriate expression of their genes requires chromosomes to fold into complex three-dimensional structures. Transcriptional control involves the establishment of physical connections among genes and regulatory elements, both along and between chromosomes. Recent technological innovations in probing the folding of chromosomes are providing new insights into the spatial organization of genomes and its role in gene regulation. It is emerging that folding of large complex chromosomes involves a hierarchy of structures, from chromatin loops that connect genes and enhancers to larger chromosomal domains and nuclear compartments. The larger these structures are along this hierarchy, the more stable they are within cells, while becoming more stochastic between cells. Here, we review the experimental and theoretical data on this hierarchy of structures and propose a key role for the recently discovered topologically associating domains.</p>
dc.identifier.submissionpathsysbio_pubs/20
dc.contributor.departmentDepartment of Biochemistry and Molecular Pharmacology
dc.contributor.departmentProgram in Systems Biology
dc.source.pages773-82


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