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    A compendium of Caenorhabditis elegans RNA binding proteins predicts extensive regulation at multiple levels

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    Authors
    Tamburino, Alex M.
    Ryder, Sean P.
    Walhout, Albertha J. M.
    UMass Chan Affiliations
    Department of Biochemistry and Molecular Pharmacology
    Program in Molecular Medicine
    Program in Systems Biology
    Document Type
    Journal Article
    Publication Date
    2013-02-01
    Keywords
    RNA-Binding Proteins
    Caenorhabditis elegans
    RNA Processing, Post-Transcriptional
    Gene Expression Regulation
    Genetics and Genomics
    Molecular Genetics
    Systems Biology
    
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    Link to Full Text
    http://www.g3journal.org/content/suppl/2013/02/09/3.2.297.DC1/004390SI.pdf
    Abstract
    Gene expression is regulated at multiple levels, including transcription and translation, as well as mRNA and protein stability. Although systems-level functions of transcription factors and microRNAs are rapidly being characterized, few studies have focused on the posttranscriptional gene regulation by RNA binding proteins (RBPs). RBPs are important to many aspects of gene regulation. Thus, it is essential to know which genes encode RBPs, which RBPs regulate which gene(s), and how RBP genes are themselves regulated. Here we provide a comprehensive compendium of RBPs from the nematode Caenorhabditis elegans (wRBP1.0). We predict that as many as 887 (4.4%) of C. elegans genes may encode RBPs ~250 of which likely function in a gene-specific manner. In addition, we find that RBPs, and most notably gene-specific RBPs, are themselves enriched for binding and modification by regulatory proteins, indicating the potential for extensive regulation of RBPs at many different levels. wRBP1.0 will provide a significant contribution toward the comprehensive delineation of posttranscriptional regulatory networks and will provide a resource for further studies regulation by RBPs.
    Source
    G3 (Bethesda). 2013 Feb;3(2):297-304. doi: 10.1534/g3.112.004390. Link to article on publisher's site

    DOI
    10.1534/g3.112.004390
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/49905
    PubMed ID
    23390605
    Related Resources
    Link to Article in PubMed
    Rights

    This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/ by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

    ae974a485f413a2113503eed53cd6c53
    10.1534/g3.112.004390
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