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dc.contributor.authorTamburino, Alex M.
dc.contributor.authorRyder, Sean P.
dc.contributor.authorWalhout, Albertha J. M.
dc.date2022-08-11T08:10:59.000
dc.date.accessioned2022-08-23T17:27:38Z
dc.date.available2022-08-23T17:27:38Z
dc.date.issued2013-02-01
dc.date.submitted2013-04-08
dc.identifier.citationG3 (Bethesda). 2013 Feb;3(2):297-304. doi: 10.1534/g3.112.004390. <a href="http://dx.doi.org/10.1534/g3.112.004390" target="_blank">Link to article on publisher's site</a></p>
dc.identifier.issn2160-1836 (Linking)
dc.identifier.doi10.1534/g3.112.004390
dc.identifier.pmid23390605
dc.identifier.urihttp://hdl.handle.net/20.500.14038/49905
dc.description.abstractGene expression is regulated at multiple levels, including transcription and translation, as well as mRNA and protein stability. Although systems-level functions of transcription factors and microRNAs are rapidly being characterized, few studies have focused on the posttranscriptional gene regulation by RNA binding proteins (RBPs). RBPs are important to many aspects of gene regulation. Thus, it is essential to know which genes encode RBPs, which RBPs regulate which gene(s), and how RBP genes are themselves regulated. Here we provide a comprehensive compendium of RBPs from the nematode Caenorhabditis elegans (wRBP1.0). We predict that as many as 887 (4.4%) of C. elegans genes may encode RBPs ~250 of which likely function in a gene-specific manner. In addition, we find that RBPs, and most notably gene-specific RBPs, are themselves enriched for binding and modification by regulatory proteins, indicating the potential for extensive regulation of RBPs at many different levels. wRBP1.0 will provide a significant contribution toward the comprehensive delineation of posttranscriptional regulatory networks and will provide a resource for further studies regulation by RBPs.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23390605&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://www.g3journal.org/content/suppl/2013/02/09/3.2.297.DC1/004390SI.pdf
dc.rights<p>This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/ by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p>
dc.subjectRNA-Binding Proteins
dc.subjectCaenorhabditis elegans
dc.subjectRNA Processing, Post-Transcriptional
dc.subjectGene Expression Regulation
dc.subjectGenetics and Genomics
dc.subjectMolecular Genetics
dc.subjectSystems Biology
dc.titleA compendium of Caenorhabditis elegans RNA binding proteins predicts extensive regulation at multiple levels
dc.typeJournal Article
dc.source.journaltitleG3 (Bethesda, Md.)
dc.source.volume3
dc.source.issue2
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1022&amp;context=sysbio_pubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/sysbio_pubs/23
dc.identifier.contextkey4007878
refterms.dateFOA2022-08-23T17:27:38Z
html.description.abstract<p>Gene expression is regulated at multiple levels, including transcription and translation, as well as mRNA and protein stability. Although systems-level functions of transcription factors and microRNAs are rapidly being characterized, few studies have focused on the posttranscriptional gene regulation by RNA binding proteins (RBPs). RBPs are important to many aspects of gene regulation. Thus, it is essential to know which genes encode RBPs, which RBPs regulate which gene(s), and how RBP genes are themselves regulated. Here we provide a comprehensive compendium of RBPs from the nematode Caenorhabditis elegans (wRBP1.0). We predict that as many as 887 (4.4%) of C. elegans genes may encode RBPs ~250 of which likely function in a gene-specific manner. In addition, we find that RBPs, and most notably gene-specific RBPs, are themselves enriched for binding and modification by regulatory proteins, indicating the potential for extensive regulation of RBPs at many different levels. wRBP1.0 will provide a significant contribution toward the comprehensive delineation of posttranscriptional regulatory networks and will provide a resource for further studies regulation by RBPs.</p>
dc.identifier.submissionpathsysbio_pubs/23
dc.contributor.departmentDepartment of Biochemistry and Molecular Pharmacology
dc.contributor.departmentProgram in Molecular Medicine
dc.contributor.departmentProgram in Systems Biology
dc.source.pages297-304


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