Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data
UMass Chan Affiliations
Department of Biochemistry and Molecular PharmacologyProgram in Systems Biology
Document Type
Journal ArticlePublication Date
2013-06-01
Metadata
Show full item recordAbstract
How DNA is organized in three dimensions inside the cell nucleus and how this affects the ways in which cells access, read and interpret genetic information are among the longest standing questions in cell biology. Using newly developed molecular, genomic and computational approaches based on the chromosome conformation capture technology (such as 3C, 4C, 5C and Hi-C), the spatial organization of genomes is being explored at unprecedented resolution. Interpreting the increasingly large chromatin interaction data sets is now posing novel challenges. Here we describe several types of statistical and computational approaches that have recently been developed to analyse chromatin interaction data.Source
Nat Rev Genet. 2013 Jun;14(6):390-403. doi: 10.1038/nrg3454. Epub 2013 May 9. Link to article on publisher's siteDOI
10.1038/nrg3454Permanent Link to this Item
http://hdl.handle.net/20.500.14038/49907PubMed ID
23657480Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1038/nrg3454