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    Flexible ordering of antibody class switch and V(D)J joining during B-cell ontogeny

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    Authors
    Kumar, Satyendra
    Wuerffel, Robert
    Achour, Ikbel
    Lajoie, Bryan R.
    Sen, Ranjan
    Dekker, Job
    Feeney, Ann J.
    Kenter, Amy L.
    UMass Chan Affiliations
    Department of Biochemistry and Molecular Pharmacology
    Programs in Systems Biology
    Document Type
    Journal Article
    Publication Date
    2013-11-15
    Keywords
    B-cell development
    Ag gene rearrangement
    Gene expression
    Developmental Biology
    Genetics and Genomics
    Systems Biology
    
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    Link to Full Text
    http://dx.doi.org/10.1101/gad.227165.113
    Abstract
    V(D)J joining is mediated by RAG recombinase during early B-lymphocyte development in the bone marrow (BM). Activation-induced deaminase initiates isotype switching in mature B cells of secondary lymphoid structures. Previous studies questioned the strict ontological partitioning of these processes. We show that pro-B cells undergo robust switching to a subset of immunoglobulin H (IgH) isotypes. Chromatin studies reveal that in pro-B cells, the spatial organization of the Igh locus may restrict switching to this subset of isotypes. We demonstrate that in the BM, V(D)J joining and switching are interchangeably inducible, providing an explanation for the hyper-IgE phenotype of Omenn syndrome.
    Source
    Kumar S, Wuerffel R, Achour I, Lajoie B, Sen R, Dekker J, Feeney AJ, Kenter AL. Flexible ordering of antibody class switch and V(D)J joining during B-cell ontogeny. Genes Dev. 2013 Nov 15;27(22):2439-44. doi: 10.1101/gad.227165.113. Link to article on publisher's site
    DOI
    10.1101/gad.227165.113
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/49920
    PubMed ID
    24240234
    Notes

    © 2013 Kumar et al.; Published by Cold Spring Harbor Laboratory Press.

    This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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    Link to Article in PubMed
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    10.1101/gad.227165.113
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