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    Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans Gene Expression and Life History Traits

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    Authors
    Watson, Emma
    MacNeil, Lesley T.
    Ritter, Ashlyn D.
    Yilmaz, L. Safak
    Rosebrock, Adam P.
    Caudy, Amy A.
    Walhout, Albertha J. M.
    UMass Chan Affiliations
    Program in Molecular Medicine
    Program in Systems Biology
    Document Type
    Journal Article
    Publication Date
    2014-02-13
    Keywords
    Cell and Developmental Biology
    Cellular and Molecular Physiology
    Genetics and Genomics
    Molecular Biology
    Molecular, Genetic, and Biochemical Nutrition
    Systems Biology
    
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    Link to Full Text
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169190/
    Abstract
    Diet greatly influences gene expression and physiology. In mammals, elucidating the effects and mechanisms of individual nutrients is challenging due to the complexity of both the animal and its diet. Here, we used an interspecies systems biology approach with Caenorhabditis elegans and two of its bacterial diets, Escherichia coli and Comamonas aquatica, to identify metabolites that affect the animal's gene expression and physiology. We identify vitamin B12 as the major dilutable metabolite provided by Comamonas aq. that regulates gene expression, accelerates development, and reduces fertility but does not affect lifespan. We find that vitamin B12 has a dual role in the animal: it affects development and fertility via the methionine/S-Adenosylmethionine (SAM) cycle and breaks down the short-chain fatty acid propionic acid, preventing its toxic buildup. Our interspecies systems biology approach provides a paradigm for understanding complex interactions between diet and physiology.
    Source
    Watson E, Macneil LT, Ritter AD, Yilmaz LS, Rosebrock AP, Caudy AA, Walhout AJ. Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans Gene Expression and Life History Traits. Cell. 2014 Feb 13;156(4):759-70. doi:10.1016/j.cell.2014.01.047. Link to article on publisher's website
    DOI
    10.1016/j.cell.2014.01.047
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/49924
    PubMed ID
    24529378
    Notes

    First author Emma Watson is a doctoral student in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.

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    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.cell.2014.01.047
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