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    Let a hundred flowers bloom: the role of context dependence in creating phenotypic diversity following targeted therapy

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    Authors
    Lee, Michael J.
    UMass Chan Affiliations
    Program in Systems Biology
    Document Type
    Journal Article
    Publication Date
    2015-03-05
    Keywords
    Cancer Biology
    Cell Biology
    Computational Biology
    Molecular Biology
    Systems Biology
    
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    Link to Full Text
    http://dx.doi.org/10.1016/j.molcel.2015.02.030
    Abstract
    Using a newly developed computational platform, COSPER, Litvin et al. (2015) identify context-dependent interactions between MEK and interferon signaling that underlie sensitivity and resistance to MEK inhibition in melanoma.
    Source
    Mol Cell. 2015 Mar 5;57(5):763-4. doi: 10.1016/j.molcel.2015.02.030. Link to article on publisher's site
    DOI
    10.1016/j.molcel.2015.02.030
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/49941
    PubMed ID
    25747655
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.molcel.2015.02.030
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