Structural and functional diversity of Topologically Associating Domains
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UMass Chan Affiliations
Department of Biochemistry and Molecular PharmacologyProgram in Systems Biology
Document Type
Journal ArticlePublication Date
2015-10-07Keywords
Chromatin foldingLong-range gene regulation
Topologically associating domain
Biochemistry, Biophysics, and Structural Biology
Genomics
Systems Biology
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Show full item recordAbstract
Recent studies have shown that chromosomes in a range of organisms are compartmentalized in different types of chromatin domains. In mammals, chromosomes form compartments that are composed of smaller Topologically Associating Domains (TADs). TADs are thought to represent functional domains of gene regulation but much is still unknown about the mechanisms of their formation and how they exert their regulatory effect on embedded genes. Further, similar domains have been detected in other organisms, including flies, worms, fungi and bacteria. Although in all these cases these domains appear similar as detected by 3C-based methods, their biology appears to be quite distinct with differences in the protein complexes involved in their formation and differences in their internal organization. Here we outline our current understanding of such domains in different organisms and their roles in gene regulation.Source
FEBS Lett. 2015 Oct 7;589(20 Pt A):2877-84. doi: 10.1016/j.febslet.2015.08.044. Epub 2015 Sep 5. Link to article on publisher's siteDOI
10.1016/j.febslet.2015.08.044Permanent Link to this Item
http://hdl.handle.net/20.500.14038/49953PubMed ID
26348399Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.febslet.2015.08.044