UMass Chan AffiliationsDepartment of Biochemistry and Molecular Pharmacology
Program in Systems Biology
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AbstractTo accommodate genomes in the limited space of the cell nucleus and ensure the correct execution of gene expression programs, genomes are packaged in complex fashion in the three-dimensional cell nucleus. As a consequence of the extensive higher-order organization of chromosomes, distantly located genomic regions on the same or distinct chromosomes undergo long-range interactions. This article discusses the nature of long interactions, mechanisms of their formation, and their emerging functional roles in gene regulation and genome maintenance.
SourceCold Spring Harb Perspect Biol. 2015 Oct 1;7(10). pii: a019356. doi: 10.1101/cshperspect.a019356.. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/49954
Related ResourcesLink to Article in PubMed