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dc.contributor.authorDekker, Job
dc.contributor.authorMisteli, Tom
dc.date2022-08-11T08:11:00.000
dc.date.accessioned2022-08-23T17:27:51Z
dc.date.available2022-08-23T17:27:51Z
dc.date.issued2015-10-01
dc.date.submitted2015-10-29
dc.identifier.citationCold Spring Harb Perspect Biol. 2015 Oct 1;7(10). pii: a019356. doi: 10.1101/cshperspect.a019356.. <a href="http://dx.doi.org/10.1101/cshperspect.a019356">Link to article on publisher's site</a>
dc.identifier.issn1943-0264 (Electronic)
dc.identifier.doi10.1101/cshperspect.a019356
dc.identifier.pmid26430217
dc.identifier.urihttp://hdl.handle.net/20.500.14038/49954
dc.description.abstractTo accommodate genomes in the limited space of the cell nucleus and ensure the correct execution of gene expression programs, genomes are packaged in complex fashion in the three-dimensional cell nucleus. As a consequence of the extensive higher-order organization of chromosomes, distantly located genomic regions on the same or distinct chromosomes undergo long-range interactions. This article discusses the nature of long interactions, mechanisms of their formation, and their emerging functional roles in gene regulation and genome maintenance.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=26430217&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1101/cshperspect.a019356
dc.subjectGenomics
dc.subjectMolecular Biology
dc.subjectSystems Biology
dc.titleLong-Range Chromatin Interactions
dc.typeJournal Article
dc.source.journaltitleCold Spring Harbor perspectives in biology
dc.source.volume7
dc.source.issue10
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/sysbio_pubs/74
dc.identifier.contextkey7778182
html.description.abstract<p>To accommodate genomes in the limited space of the cell nucleus and ensure the correct execution of gene expression programs, genomes are packaged in complex fashion in the three-dimensional cell nucleus. As a consequence of the extensive higher-order organization of chromosomes, distantly located genomic regions on the same or distinct chromosomes undergo long-range interactions. This article discusses the nature of long interactions, mechanisms of their formation, and their emerging functional roles in gene regulation and genome maintenance.</p>
dc.identifier.submissionpathsysbio_pubs/74
dc.contributor.departmentDepartment of Biochemistry and Molecular Pharmacology
dc.contributor.departmentProgram in Systems Biology


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