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UMass Chan Affiliations
Department of Biochemistry and Molecular PharmacologyProgram in Systems Biology
Document Type
Journal ArticlePublication Date
2016-03-10Keywords
CTCFHi-C
biophysics
cohesin
condensin
domains
enhancer
gene expression
gene regulation
polymers
promoter
simulations
Biochemistry
Biophysics
Computational Biology
Genomics
Molecular Biology
Structural Biology
Systems Biology
Metadata
Show full item recordAbstract
Proper expression of genes requires communication with their regulatory elements that can be located elsewhere along the chromosome. The physics of chromatin fibers imposes a range of constraints on such communication. The molecular and biophysical mechanisms by which chromosomal communication is established, or prevented, have become a topic of intense study, and important roles for the spatial organization of chromosomes are being discovered. Here we present a view of the interphase 3D genome characterized by extensive physical compartmentalization and insulation on the one hand and facilitated long-range interactions on the other. We propose the existence of topological machines dedicated to set up and to exploit a 3D genome organization to both promote and censor communication along and between chromosomes.Source
Cell. 2016 Mar 10;164(6):1110-21. doi: 10.1016/j.cell.2016.02.007. Link to article on publisher's siteDOI
10.1016/j.cell.2016.02.007Permanent Link to this Item
http://hdl.handle.net/20.500.14038/49959PubMed ID
26967279Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.cell.2016.02.007